| ObjectHand,foot and mouth disease as a higher incidence of intestinal infectious diseases,a district of Tianjin residents a greater impact on health,in order to master the area of hand,foot and mouth disease epidemic,The epidemiological characteristics of hand,foot and mouth disease in 2010 ? 2016,and the description and analysis of hand-foot-mouth disease aggregation,death cases,pathogen surveillance,EV71 neutralization antibody monitoring and EV71 vaccination were provided for future prevention and control of hand,foot and mouth disease Scientific analysis of the conclusions,the development of scientific and effective prevention and control strategies.MethodThe epidemiological reports and pathogens of the hand-foot-mouth disease from 2010 to 2016 were analyzed,and the epidemiological patterns and characteristics were analyzed by descriptive analysis.The correlation analysis was used to analyze the epidemic situation Timeliness and duration of the analysis.Result 1?2010?2016 Tianjin District cumulative report of hand,foot and mouth disease in 8431 cases,of which 5 cases of severe cases,3 cases of death cases,reported a total of 111 cases of epidemic outbreaks,outbreaks 1.The highest incidence of 269.47 / 10 million,the lowest is 118.37 / 10 million,although a downward trend,but the annual average higher than the city's incidence level.The epidemic curve showed a single peak or bimodal epidemic pattern,the annual peak is generally in June-July,seasonal characteristics of the disease significantly.2?The area of hand,foot and mouth disease incidence of the streets in the distribution of Jinzhong Street,Xinli Street,Wanxin Street occupy the top three,hand,foot and mouth disease aggregation occurred mainly in nurseries,scattered children appear more serious cases of death.The incidence of children concentrated in children under the age of 5,82.18% of the disease composition,scattered children accounted for 62.29% of the incidence of sex,male and female sex ratio of 1.5: 1 total.Death cases mainly occur in children under 3 years of age,diagnosis and treatment of delay is the main reason,should strengthen the early identification of severe tendencies and clinical monitoring.3?The positive rates of CVA16,EV71,CVA6 and CVA10 were 28.88%,24.96%,13.01% and 2.32%,respectively.The CVA6 was the most prevalent in recent years.The higher proportion,but EV71 or cause serious cases of severe death of the main pathogens,other enterovirus EV need further typing clear.4?The epidemic situation of the hand,foot and mouth disease in this area is mainly distributed in the private care and child care and public kindergartens,accounting for 46.85% and 27.93% of the total epidemic,respectively.The nursery school is an important place for the occurrence of hand,foot and mouth disease.The epidemiological report was 50.45%,the average duration of the epidemic was 6.35 days,the shortest was 2 days and the longest was 25 days.The timeliness of the report was closely related to the duration of the epidemic,the more timely the report,the epidemic The shorter the time,r = 0.885,P = 0.000.5?From 2010 to 2016,the positive rate of EV71 neutralizing antibody in the healthy population showed that the positive rate of male antibody was 66.12%,the positive rate of female antibody was 76.10%,the age group with the lowest positive rate in 5 age groups was 1?5 years old,and the positive rate of male antibody was 66.12% With the increase in age,followed by ascending,16?25 year-old positive rate reached its peak,and then in the 26?35 age group has declined.The lowest rate of recessive infection was 7.50% in 2010,followed by a maximum of 55.00% in 2014.The overall positive rate of neutralizing antibody was 71.79%,and the cumulative total hidden infection rate was 28.21%.Antibody positive rate of the lowest 1-5 years group for the susceptible population,6 years old and above the group of hidden infection rate is high and is an important source of infection.6?Hand,foot and mouth disease vaccine has broad prospects,the unit price vaccine is a good start,safe and effective and low cost of multi-dose vaccine is the ultimate goal.The area in 2016 a total of 477 school-age children vaccinated EV71 vaccine,after months of observation,the protection rate of 100%.ConclusionAlthough the incidence of hand,foot and mouth disease in Tianjin from 2010 to 2016 is declining,it is still higher than the average level of the city.The main cause of the infestation,especially the private undocumented epidemic,is 5 years old and below Children,male incidence accounted for significant advantages,the lack of severe cases of death in the early identification of critical and clinical care.Adult EV71 recessive infection rate is higher,children with neutral antibody positive rate is low,the lack of protective antibodies is also a child susceptible to the crowd factors.EV71 vaccine listed time is shorter,the area of vaccination data showing a better protection,and now face a variety of intestinal virus epidemic coexistence of the status quo,multi-price hand,foot and mouth disease vaccine is the key to future prevention and treatment of hand,foot and mouth disease. |
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