The Survey And Analysis Of Serum Vitamin A And E Levels In Pregnant Women

ObjectiveTo investigate the serum vitamin A and E levels in the early(11-13 + 6 weeks),middle(24-25 + 6 weeks)and late(?31 weeks)pregnancy,and analyze its related influencing factors and its relationship with the pregnancy disease.Provide evidence fpregnant women to make reasonable nutrition guidance.MethodsA total of 2740 single pregnant women were enrolled in Tianjin Center Obstetrics and Gynecology Hospital from October 2015 to March 2016.Determination by high performance liquid chromatography(HPLC)Peripheral serum vitamin A,E concentration.At the same time,collect diet and drug supplement of pregnant women through the form of question and answer questionnaire and record the general information and final pregnancy outcomes.Pregnancy outcome as the dependent variable(suffering from a disease = 1,not suffering from a disease = 0),peripheral blood vitamin A,E levels,age of pregnancy as an independent variable.Logistic regression analysis was used to analyze the relationship between vitamin A and E levels,the age of pregnancy and the outcome of pregnancy in pregnant women.Results1.In early,middle and late pregnancy vitamin A serum value were(0.47 ± 0.095)mg / L,(0.48 ± 0.323)mg / L,(0.39 ± 0.111)mg / L,The overall abnormal rate was11.71%,main performence is lack(88.81%).The lowest level and the highest abnormal rate(19.65%)of vitamin A was in the late pregnancy(P <0.05),which severe deficiency rate(<0.2mg / L)was 6.72%.2.The serum levels of vitamin E in early,middle and late pregnancy were(11.33 ± 2.521)mg / L,(15.78 ± 3.493)mg / L,(17.99 ± 4.571)mg / L,the overall abnormal rate of vitamin E during pregnancy was 16.21%,mainly in excess(99.75%)(P = 0.00,P <0.05).With the increase of gestational age,the concentration andabnormal rate of vitamin E were increased;The highest level and excess rate of vitamin E was in late pregnancy(P = 0.000,P<0.05,26.83%).3.Vitamin E concentration and age,pregnancy times,and birth times was positively correlated,but in the late pregnancy,vitamin E concentration and pregnancy times and birth times was negative correlation and when the age of pregnant women was ? 40,the vitamin E levels showed a downward trend.4.On the basis of daily diets,the intake of nuts increased in early pregnancy,while the concentration of vitamin A and E increased.And the concentration of vitamin A and E increased with the increase of intake of the daily meat and visceral.In the conditions of similar basic dietary situation,adding the same multi-vitamins containing vitamin A,E in early pregnancy the serum vitamin A,E concentration is higher than only adding in the middle and late pregnancy.5.The serum vitamin A,E concentration in the middle and late pregnancy had no significant effect on pregnancy-related hypertension(except for chronic hypertension with pregnancy and eclampsia),PROM and PPROM.6.The concentration of vitamin A and E in pregnant women was correlated with the occurrence of GDM(P <0.05).When vitamin A and E concentrations in the normal range(vitamin A concentration was 0.3-0.7mg / L,vitamin E concentration was 5-20 mg / L)was the protective factor of GDM.Adding multivitamins in early pregnancy can significantly reduce the incidence of GDM.Excess of vitamin E in GDM group was significantly higher than that in non-GDM group.The higher the age of gestation,the higher the risk of GDM in our study population.Conclusion1.The abnormal of vitamin A is mainly lack,so recommend that women should add vitamin A regularly enough during pregnancy;The abnormal of vitamin E is mainly excessive,accounting for 99.75%,so the concentration should be monitored before a reasonable supplement.On the basis of daily diet,adding multivitamins in early pregnancy can effectively improve the vitamin A,E deficiency.2.Vitamin A and E concentrations during pregnancy are affected by a variety of factors,such as the age of women,pregnancy times,birth times and diet.Women should be regularly monitored nutrition situation,nutrition guidance should beaccording to the needs of individual needs to avoid excessive vitamin E.3.Suggest that the high risk of GDM pregnant women should add multivitamins containing vitamin A,E in the early pregnancy to prevent the occurrence of GDM to improve pregnancy outcome.4.As whether the lack or excessive of vitamin A?E,the risk of GDM is increased,when add vitamin A,E during pregnancy,obstetrician should monitor the level of vitamin A?E regularly.