Analysis On The Pathological Features Of 580 Cases Of Lymphoma In Zunyi Region Based On The New Classification Standard Of WHO

Objective: According to the new classification of WHO lymphatic hematopoietic system tumor,the pathological features of lymphoma in Zunyi area were analyzed to provide data support for the collection of national multi center lymphoma cases.Methods: From January 2006 ~2016 year in December in Affiliated Hospital of Zunyi Medical College,the first people’s Hospital of Zunyi,Zunyi aerospace hospital,Fifth People’s Hospital of Zunyi city and Zunyi area in Affiliated Hospital of Zunyi Medical College consultation,clinical pathology and immunophenotype examination confirmed ML cases according to the 2016 WHO classification of the new standard for the re identification and classification,and analyzed the age,sex,first location,symptoms,pathological type and other characteristics.Results: There were 580 cases of malignant lymphoma(ML)in the study,the ratio of male to female was 2.09:1,the median age was 53 years,the average age was(49.9 + 19.4)years,the age of onset was 1~86 years,and the peak was 61~65 years old.Hodgkin’s lymphoma(HL)lesion on lymph node disease accounted for 93.4%,lymph tissue disease accounted for 8.7%;non Hodgkin’s lymphoma(NHL)lymph nodes were accounted for43.6%,the top three were cervical lymph node 28.5%,inguinal lymph node 6.9%,submandibular lymph nodes accounted for 56.4% to 2.6%,the onset nodes,the top three were digestive system accounted for 15.5%,14.2%,5.1% ML nasal tonsil;systemic symptoms include fever,night sweats,(47.6%)(7.3%),skin itching(3.4%)and weight loss(16.7%);superficial lymph node enlargement of lymph node enlargement onset of local symptoms(including the neck,inguinal,axillary and submandibular lymph nodes);(37.7%)to local lymph node symptoms onset before three: digestive system(hematemesis,melena,diarrhea,constipation)(18%),the nasopharynx(nasal pharynx,sai Department of tumor,dysphagia,tonsil enlargement,pharyngeal foreign body sensation,epistaxis,hoarseness,tinnitus)(31.4%),abdominal symptoms(abdominal pain,abdominal distension,abdominal mass)(1.7%);according to the pathological type in 580 cases of ML patients with HL46(7.6%),NHL534(92.1% cases).HL with mixed cell type Hodgkin lymphoma(MCCHL)(37%)and Hodgkin’s lymphoma nodular sclerosis type(NSCHL)(26.1%);B cell lymphoma NHL cell lymphoma T/NK accounted for 72.8%,accounting for 27.2%;the most common pathological type of NHL of the top five were diffuse large B cell lymphoma,non special type(DLCBL-NOS)(46.6%),extranodal NK/T cell lymphoma,nasal type(ENK-T/NT)(12.9%),mucosa associated lymphoid tissue extranodal marginal zone lymphoma(MALT)(8.2%),mantle cell lymphoma(MCL)(5.2%)and peripheral T cell lymphoma,non special type(PTCL-NOS)(3.9%);the distribution of the tumors in Zunyi area HL group and NHL group,age difference(P < 0.05),no gender difference(P >0.05);There were differences in sex distribution between Zunyi and other countries(P <0.05),and there was no difference in location(P > 0.05);the overall distribution of HL and NHL in Zunyi area was different from other countries and regions(P < 0.05).Conclusion: According to the new classification of WHO lymphatic hematopoietic system tumor,the pathological features of 580 cases of lymphoma in Zunyi area are as follows:(1)The age of onset and gender: the overall peak incidence is slower,the incidence of men is higher,HL is earlier than the age of onset of NHL,most subtypes have been male dominated,especially MCL,but FL,BL and LRCHL have higher incidence of female;(2)The location of the disease and the symptoms of the first symptom were mainly fever,and the local first symptom was mainly lymph node enlargement.HL in cervical lymph nodes,extranodal sites of NHL onset rare;the incidence of extranodal lymph nodes than the onset of onset,nodal cervical lymph node,extranodal sites of onset were the top three of the digestive tract,nasal cavity and tonsil;(3)Pathological type: HL MCCHL;B cell lymphoma NHL cell lymphoma is more than T/NK,NHL in the top three are DLCBL-NOS,ENK-T/NT and MALT;ML at home and abroad in Zunyi,not the majority of the ML subtype difference at home and abroad,but DLBCL,MCL and ENK-T/NT higher than the proportion of the domestic and foreign regions,FL and CLL/SLL were lower than the domestic and foreign regions.