Expressions Of FOXC1 And E-Cadherin In Gastric Cancer Tissues And Their Relationships With Pathological Characteristics

Objective: To analyze and compare the expressions of forkhead box C1(FOXC1)and E-cadherin and in between gastric cancer and paracancerous tissues.To determine the correlations of the two factor expressions with pathological features,thus providing implications for cancer treatment and prognosis prediction.Methods: A total of 102 gastric cancer patients who underwent surgery wererandomly included into the current study.After excluding 1 case of other organ processed into paraffin-embedded sections for two-step biotin-free immunohistochemistry(IHC)detection.The expressions of the two factors were detected,and statistical differences analyzed.The relationships between the expression levels and pathological features were further explored.Results:(1)The positive expression rate of FOXC1 is 73.74% in gastric cancer group and that is 44.44% in paraneoplastic group.Both have significant statistical differences(P <0.05).(2)The positive expression rate of E-Cadherin is 29.29% in gastric cancer group and that is 73.74% in paraneoplastic group.There are statistical differences between the gastric cancer group and the paraneoplastic group.(P <0.05).(3)The expression of FOXC1 was not significantly different between cases of different ages or genders(P>0.05).But it was significantly different between case s with distinct TNM classifications,histological subtypes and invasive depths,and presence or absence of lymph node metastasis(P<0.05).Similarly,the expression o f E-cadherin was not significantly different between cases divided by ages or gend ers(P>0.05).But significantly different between cases divided by TNM classificatio ns,histological subtypes,invasive depths and lymph node metastasis(P<0.05).expre ssion of FOXC1 and E-Cadherin gene in the gastric tissues of correlation,X2=54.31,r=-0.889,(P<0.05).expression of FOXC1 and E-Cadherin gene in the paraneoplastic ti ssues of correlation,X2=69.02,r=0.789,(P<0.05).Conclusion:(1)For the two factors(FOXC1 and E-cadherin)may play some roles in the carcinogenesis,development,invasion and metastasis of gastric cancer.They provide implications for the mechanisms underlying gastric oncogenesis.Moreover,FOXC1 expression may also be associated with the downregulation of E-cadherin expression.FOXC1 probably regulates E-cadherin expression,thus affecting epithelial-mesenchymal transition in gastric cancer.