The Investigate Of The TIVAP Catheter Related Thrombosis In Breast Cancer Patients With Chemotherapy

ObjectiveTo investigate the incidence,risk factors and treatment of the Totally implantable venous access port(T?AP)related thrombosis in the breast cancer patients after chemotherapy,which can provide a basis for preventing the Catheter-related thrombosis of T?AP.MethodsUsing the current situation investigation to investigate the breast cancer who hospitalization from April 1st 2015 to April 1st,2016,colle ct the patients' general information,results of Color Doppler ultrasoundon neck,results of Laboratory test.Using SPSS16.0 to statistic analys is,Measurement data using t test,counting data by chi-square test or ra nk and logistics analysis,IF P < 0.05,it indicates that there is signific ant difference.The diagnosis standard of the catheter-related thrombosis in our study is the Color Doppler ultrasound for blood vessels,local c linical symptoms and opinions of professor in the vascular surgery d epartement.Results(1)A total of 190 cases were investigated,and there were 108(56.8%)patients were found catheter-related asymptomatic thrombosis,only 4 c ases were found symptomatic thrombosis,the incidence was 2.1%.(2)T he incidence of catheter-related thrombosis was 88.9%(16/18)in the patients who were more than 60 years,There are significant difference(P=0.021<0.05)in the groups whoes ages was?40,41~59 and ?60.The incidence of thrombosis was highest in the breast cancers patients whoe s whoes age was ?60.(3)The incidence of thrombosis was 71.9%(46/64)in the breast cancers patients whoes clinical stage was ?~?.and there were significant difference(P=0.012<0.05)between the clinical sta ge were I~II and ?~?)groups.The incidence of thrombosis was hig her in the breast cancers patients whoes clinical stage was TEC.(4)Th e incidence of catheter-related thrombosis was 66.1%(74/112)in the patients whoes chemotherapy regimen was TEC(docetaxel combinede p irubicinandcyclophosphamide).When the Patients were be divided into g roups TEC,EC_T(Epirubicin combine cyclophosphamide four period bef ore docetaxel),CEF(cyclophosphamide combine Epirubicin and Fluorour acil))groups by different chemotherapy regimens,and there were signifi cant difference(P=0.03<0.05).The incidence of thrombosis was highest in the breast cancers patients whoes chemotherapy regimens was TEC.(5)As far as catheter-related thrombosis of breast cancer patients,there were no significant difference in different murals,and periods of chemo therapy and so on.(6)there were significant difference compared the re sult before infusion the T?AP,The FIB and D-dimer were elevated w hen the thrombosis was diagnosised.ConclusionThe catheter-related symptomatic thrombosis incidence is low,asymptomatic thrombosis incidence is high,the incidence of catheter-re lated thrombosis was different in patients with different ages\clinical sta ges of malignancy\chemotherapy regimens.Besides,the FIB and D-D is increase when catheter-related thrombosis is found;But only Ages was the risk factor in our study.Because asymptomatic thrombosis incidenc e is high,We should pay due attention in breast cancer patients who wi th T?AP,so that the T?AP would function well.When found catheterrelated asymptomatic thrombosis,the PORT should not be moved so spe edy,after closely monitored and anticoagulant therapy,the port would no t be destoryed.