Hepatitis C And Risk Of Coronary Atherosclerosis-meta Analysis

Aims: The effect of Hepatitis C virus(HCV)infection on coronary atherosclerosis risk remains ambiguous.This meta-analysis is to systematically assess the risk of cardiovascular disease in HCV patients..Methods: We searched CNKI and Wan Fang database,PubMed Central,Scopus,Embase,Cochrane Library,CBM,.Thirteen studies were included in this meta-analysis based on the inclusion criteria.The qualities of included studies were assessed with Newcastle-Ottawa Scale quality assessment tools.Odds ratio was analyzed by the software of Comprehensive Meta-Analysis version 2.0 and Revman 5.0.Subgroup analyses were performed according to study design(cohort vs case-control),mean cohort age(threshold,50 y),prevalence of DM(threshold,10%)and prevalence of hypertension(threshold,>20%).Result: Compared with uninfected individuals(controls),HCV-infected patients had a higher risk of coronary atherosclerosis(odds ratio [OR],1.32;95% [CI],1.05–1.66;P < 0.05).In subgroups of age < 50 years,hypertension percentage >20% and DM percentage >20%,HCV infection significantly increased the risk of coronary atherosclerosis(OR,1.28;95%[CI]1.04-1.59,P < 0.05;OR,1.50;95% [CI]1.19-1.89,P <0.05 and OR,1.51 95% [CI]1.18-1.89,P<0.05).Conclusion: HCV infection may increase the risk of coronary atherosclerosis.