Study On The Correlation Between Serum Uric Acid (UA) Level And Venous Thromboembolism (VTE)

Aim: To explore the correlation between serum uric acid (UA) level and the formation of deep venous thrombosis (DVT).Methods: In this retrospective comparative study, the experimental group consisted of 295 hip fracture patients who were divided into three groups according to their condition at discharge. Of 295 patients, there were 42 that had pulmonary thromboembolism (PTE) induced by DVT blood clot emboli; 121 only showed DVT;132 patients who only had hip fractures constituted the control group. All three groups had basic low molecular weight heparin anti coagulation treatment, while the PTE and DVT groups further received low molecular weight heparin anti coagulation treatment once upon pathogenesis. A number of measurements (uric acid levels (UA),D-dimer (DD), alanine aminotransferase (ALT), serum creatinine (Cr), urea (BUN)and brain natriuretic peptide (BNP)) were observed in both experimental groups at admittance, upon pathogenesis and on the 1st, 4th and 7th day after treatment onset.Additionally, the experimental groups’ systolic blood pressure (SBP), heart rate,respiratory rate (RR), oxygen saturation (Sp02) and daily urine output were monitored as well. At the same time, every day since admittance the control group’s measurements were taken, including UA, DD, ALT, Cr, BUN, BNP levels, SBP, heart rate, Sp 02 and daily urine output.Results :1、The three groups’ UA levels at admittance showed no statistically significant difference (p>0.05).2、At pathogenesis, the PTA group’s UA levels were significantly higher than those of the DVT and control groups (p<0.05), while the DVT group’s level was higher than the control group’s (p<0.05).3、While their condition stabilized, the PTE and DVT groups’ UA levels gradually dropped to stable levels, but the difference to the control group was not statistically significant (p>0.05).4、At admittance, however, the control group’s UA level was elevated;although after three weeks of observation, their UA levels showed signs of stabilization, the difference was not statistically significant (p>0.05).5、At PTE pathogenesis, PTE patients’ D-dimer, BNP and heart rate were statistically significantly higher than the DVT group’s and control group’s (p<0.05);furthermore, the PTE group’s oxygen saturation was lower than the DVT and control groups’ (p<0.05).6、While their condition stabilized, the d-dimer, BNP and heart rate gradually normalized, while oxygen saturation rose gradually. After one week they showed signs of stabilization. The difference from the DVT and control groups was not statistically significant (p>0.05).Conclusions: Serum UA levels at pathogenesis in hip fracture patients with DVT or PTE are elevated, but as their condition stabilizes, UA levels gradually drop to stable levels. Thus, testing serum UA levels at pathogenesis has clinical significance, as rising UA levels can indicate imminent DVT or PTE formation.