Real World Study Of Hbc With Ruangan Pill Combined With Chinese Medicine Treatment And The Correlation Of TCM Syndromes And Liver Reserve Function,portal Hypertension

Objective : To analyze the distribution of TCM syndromes and the effect of traditional Chinese medicine combined with Ruangan pill in patients with HBC combined with the real world study.Methods: The hospital information system(HIS)was used to collect the clinical data of all the patients who received the Ruangan pill with HBC in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 1,2011 to December 31,2015 including 319 cases.The cases who taking Ruangan pills were divided into Ruangan pills group and Ruangan pills combined with traditional Chinese medicine group.Then,the newly diagnosed,3 months,6 months,9 months,12 months5 observation points was studied to record the patients before and after treatment of laboratory indicators,imaging indicators,TCM syndrome changes.SPSS19.0 software was used to analyze the indexes before and after treatment in each group.The number of cases and the proportion of each syndrome were statistically analyzed.And then analyzed the correlation between different syndromes and liver reserve function and portal hypertension in HBC patients.Results: 1.Serum albumin: After 3 months,6 months,9 months,12 months the serum albumins of Ruangan pill group combined with Chinese medicine group and Ruangan pill group were all increased(P <0.05),and the Ruangan pill combined with traditional Chinese medicine group increased more obviously(P <0.05).2.Cholinesterase: After 3 months,6 months,9 months,12 months the Cholinesterases in Ruangan pill group combined with Chinese medicine group and Ruangan pill group were all increased(P <0.05),and the Ruangan pill combined with traditional Chinese medicine group increased more obviously(P <0.05).3.Portal vein velocities :After 3 months,the portal vein velocities was increased in Ruangan pill group combined with Chinese medicine group(P <0.05),but not obviously in Ruangan pill group(P> 0.05),and the increases have no difference between the two groups(P> 0.05).After 6 months,9 months,12 months the portal vein velocities were all increased in two groups(P <0.05),and the Ruangan pill combined with traditional Chinese medicine group increased more obviously(P <0.05).4.Portal vein diameter:After 3 months,the portal vein diameter was decreased in Ruangan pill group combined with Chinese medicine group(P <0.05),but not obviously in Ruangan pill group(P> 0.05),and the decreases have no difference between the two groups(P> 0.05).After 6 months,9 months,12 months the portal vein diameters of the two groups were all decreased(P <0.05),but the decreases have no difference between the two groups(P> 0.05).5.Spleen thickness:After 3 months,the spleen thickness was decreased in Ruangan pill group combined with Chinese medicine group(P <0.05),but not obviously in Ruangan pill group(P> 0.05),and the decreases have no difference between the two groups(P> 0.05).After 6 months,9 months,12 months the spleen thicknesses of the two groups were all decreased(P <0.05),and the Ruangan pill combined with traditional Chinese medicine group decreased more obviously(P <0.05).6.Spleen length:After 3 months,6 months,9 months and 12 months,the spleen lengthes of Ruangan pill group combined with Chinese medicine group and Ruangan pill group were all decreased(P <0.05),The decreases have no difference between the two groups(P> 0.05).7.TCM syndrome total points:After 3 months,6 months,9 months,12 months the TCM syndrome total points of Ruangan pill combined with Chinese medicine group and Ruangan pill group were all decreased(P <0.05),and the Ruangan pill combined with traditional Chinese medicine group decreased more obviously(P <0.05).8.Grading comparison of TCM symptoms efficacy:The total effective rates were59.68%,70.97%,80.65% and 91.13% respectively at 3 months,6 months,9 months and12 months after treatment in Ruangan pill combined with Chinese medicine group and28.17%、57.75%、64.79%、83.10% in Ruangan pill group.After 3 months,6 months,9months,12 months the efficacy in the Ruangan pill combined with Chinese medicine group was more obvious(P <0.05).9.TCM syndromes distribution: Ganyupixu syndrome is 189 cases,accounting for59.25%;Yuxuezuluo syndrome is 46 cases,accounting for 14.42%;Shireyunjie syndrome is 32 cases,accounting for 10.03%;Pixushisheng syndrome is 24 cases,7.52%;Ganshenyinxu syndrome is 21 cases,%;Pishenyangxu syndrome is 7 cases,accounting for 2.19%. 10.Comparison of TCM syndromes in the mean value of liver reserve function:serum albumin mean,Ganyupixu syndrome> Pixushisheng syndrome> Shireyunjie syndrome> Yuxuezuluo syndrome> Ganshenyinxu syndrome> Pishenyangxu syndrome.(P <0.05);Pishenyangxu syndrome and other syndrome types were statistically significant(P <0.05).There was significant difference between the two groups(P<0.05).In the cholinesterase mean,Ganyupixu syndrome> Shireyunjie syndrome>Yuxuezuluo syndrome> Pixushisheng syndrome> Ganshenyinxu syndrome>Pishenyangxu syndrome.Ganyupixu syndrome,Pishenyangxu syndrome and other syndrome types were statistically significant(P <0.05).11.Comparison of TCM syndromes in the mean value of portal hypertension:Ganyupixu> Pishenyangxu> Shireyunjie> Pixushisheng> Ganshenyinxu> Yuxuezuluo syndrome.Ganyupixu syndrome and Yuxuezuluo syndrome,Shireyunjie syndrome,Ganshenyinxu syndrome difference was statistically significant(P <0.05).In the portal vein diameter mean,Yuxuezuluo syndrome> Ganshenyinxu syndrome> Pixushisheng syndrome> Pishenyangxu syndrome> Shireyunjie syndrome> Ganyupixu syndrome.Ganyupixu syndrome and Yuxuezuluo syndrome,Pixushisheng syndrome,Ganshenyinxu syndrome was statistically significant(P <0.05);Yuxuezuluo syndrome and Shireyunjie syndrome,Ganyupixu syndrome difference was statistically significant(P <0.05).In the spleen thickness mean,Yuxuezuluo syndrome> Pishenyangxu syndrome> Ganshenyinxu syndrome> Pixushisheng syndrome> Shireyunjie syndrome>Ganyupixu syndrome.(P <0.05).There was significant difference between Yanyiyezuuo syndrome and Ganyupixu syndrome,Ganshenyinxu syndrome and Pishenyangxu syndrome(P <0.05).There was significant difference between Yuxuezuluo syndrome and Ganyupixu syndrome,Shireyunjie syndrome and Pixushisheng syndrome(P <0.05).In the spleen length mean,Yuxuezuluo syndrome> Pishenyangxu syndrome>Ganshenyinxu syndrome> Pixushisheng syndrome> Shireyunjie syndrome> Ganyupixu syndrome.(P <0.05).There were significant differences between Yuxuezuluo syndrome and Pixushisheng syndrome,Shireyunjie syndrome and Ganyupixu syndrome(P <0.05);Shireyunjie syndrome and Pixushisheng syndrome were all different from those of Yuxuezuluo syndrome(P <0.05)(P <0.05).There was significant difference between Pishenyangxu syndrome and Ganshenyinxu syndrome and Ganyupixu syndrome and Shireyunjie syndrome(P <0.05).The difference was statistically significant(P <0.05).Conclusion: 1.Ruangan pill combined with traditional Chinese medicine treatment of HBC is better than simple treatment of Ruangan pill in improving serum albumin,cholinesterase levels,increase portal flow,reduce the thickness of the spleen,improve the patient’s symptoms and signs.2.HBC TCM syndromes are followed by Ganyupixu syndrome,Yuxuezuluo syndrome,Shireyunjie syndrome,Pixushisheng syndrome,Ganshenyinxu syndrome,Pishenyangxu syndrome.Ganyupixu syndrome of the most,Pishenyangxu syndrome at least.3.The changes of TCM syndromes are correlated with the changes of liver reserve function and portal hypertension in HBC patients.