The Relationship Between Serum Level Of Anti-thyroid Peroxidase Antibody And The Intracranial Large Artery Stenosis And Short-term Outcome Of Patients With Acute Ischemic Stroke

Objective: This part of the experiments were designed to observe the effect of neuroinflammation on neuronal autophagy of mice under physiological and pathological conditions,respectively.The underlying mechanisms were also investigated.Methods: A retrospective consecutive 225 patients with acute ischemic stroke were enrolledAccording to the clinical data of brain MRA and brain CTA and DSA results,the patients were divided into intracranial large artery stenosis group(ILAS)(n = 146)and non stenosis group(non-ILAS)(n = 79).The stenosis group was divided into 1-6 group according to the degree of stenosis,each group represents one grade.The biochemical indicators,such as serum anti-thyroid peroxidase anti-body,homocysteine,C-reactive protein,uric acid,thyroid function,and blood glucose w ere measured with 24 h after admission.The National Institutes of Health Stroke Scale(NIHSS)was used to assess the neurological deficits on the day of admission.The NIHSS score <8 was defined as mild stroke and ≥8 was defined as moderate to severe stroke.At discharge or 14 d after onset,the modified Rankin Scale(mRS)was used to evaluate the clinical outcomes,0-2 was defined as good outcome and > 2 was defined as poor outcome.Results: The levels of serum anti-thyroid peroxidase anti-body in the intracranial large artery stenosis group were significantly higher than those in the none stenosis group(P < 0.01).Multivariate logistic regression analysis showed that elevated levels of serum anti-thyroid peroxidase antibody(TPO-Ab)[odds ratio(odds ratio OR)1.003,95% confidence interval(confidence,interval,CI)(1.001 ~ 1.005);P<0.05] was an independent risk factor of the intracranial large artery stenosis group(ILAS).Univariate analysis showed that admission serum anti-thyroid peroxidase anti-body levels were associated with short-term outcome(P<0.01),but after adjustment for other confounding factors,there was no statistical significance(OR:0.998,95%CI:0.993~1.002,P>0.05).Conclusion: The serum anti-thyroid peroxidase anti-body was an independent risk factor in acute ischemic stroke patients with with intracranial large artery stenosis,but it was not associated with short-term outcome.