Analysis Of Intracranial Artery Stenosis And Different Stroke Risk Population And Related Risk Factors In Jilin Province

Background: Intracranial arterial stenosis(ICAS)is a vascular lesion that is the one of the most common cause ischaemic stroke,especially in Asia.The prevalence of ICAS in China also varies by geographical location.Previous studies assessing the risk of stroke in the general population performed screening with Doppler ultrasonography only for high-risk subjects and neglected low-and moderate-risk subjects.This aims of this study were to explore the current prevalence of ICAS in stroke screening population in Jilin province in northeast China,and analyze the association between ICAS and different levels of stroke risk populations(low risk,moderate risk,high risk)and risk factors based on the risk assessment scale for stroke in China.Methods: This survey was a cross-sectional study based on population.Residents aged 40 years and over in Dehui City of Jilin Province from January to March 2016 were used as the research object.The multi-stage random cluster sampling method was used to randomly select permanent residents aged ? 40 years from different areas of urban and rural for screening to ensure that the samples are representative.Inclusion criteria: 1)complete demographic information,questionnaire survey information,and physical examination information;2)examiners with complete TCD examination results.Relevant information of all subjects was obtained by questionnaires,laboratory tests,and physical examinations,including demographic characteristics,personal life history,and related risk factors(such as smoking,drinking,hypertension,etc.).SPSS software was used to analyze the data by t-test,chi-square test,binary logistic regression and other methods.Results:(1)A total of 3654 stroke screening populations aged 40 and over were included in this study(ICAS group,n = 501,mean age 57.13±9.56 years,245 participants were male;non-ICAS group,n = 3151,1220 participants were male,mean age 55.52 ± 9.35 years old),the prevalence of ICAS in patients aged ?40 years was 13.7%.Univariate analysis of risk factors such as hypertension,drinking history,smoking history,and individual history of stroke had statistical differences between the two groups.(2)In the 501 participants with ICAS,the high-risk group accounted for 61.7%(301/501),but it should not be ignored that there were 192 low-and moderate-risk stroke groups,accounting for up to 38.3%.(3)In univariate and multivariate Logistic regression analysis,the adjusted odds ratios for ICAS in patients with moderate and high stroke risks versus those with a low stroke risk were 1.603(95% CI: 1.171-2.195)and 1.612(95% CI: 1.272-2.042),respectively.(4)After adjusting for confounding factors,there were statistically significant differences in gender,education,place of residence,hypertension,and individual stroke history and ICAS(P <0.05);The results showed that patients with hypertension and the personal history of stroke had a greater risk of ICAS,with the odds ratios of 1.655(95% CI: 1.341-2.043 and 1.854(95% CI: 1.371-2.508),respectively.Conclusion: The prevalence of ICAS is high in northeast China.Compared with the low-risk stroke population,the risk of ICAS in the moderate-and high-risk stroke population is significantly increased.hypertension is the main independent risk factors for ICAS,and individuals with a history of stroke have significantly increased risk of ICAS.In addition,the proportion of ICAS in the low-and moderate-risk stroke should also be noted.Therefore,we should increase awareness of early screening and effective prevention of ICAS and strengthen the management and control of related risk factors in order to avoid and reduce the occurrence of ICAS and stroke events.