Objective:This study was aimed to investigate a new type platelet function analyzer with two different inductive agents to detect platelet functions and access its association with recurrent ischemic stroke/TIA.Methods:The study included 738 ischemic stroke/TIA patients.On Day 0,3,and 9after antiplatelet therapy,platelet function tests were determined by Maximum aggregation rate?MAR?using a new type of PL-11 platelet function analyzer and phase matching reagents.Two induction agents were applied,including arachidonicacid?AA?and adenosine diphosphate?ADP?.At 3-month follow-up,recurrence of stroke/TIA were recorded.Results:In our study,cut-off values of adequate platelet function inhibition were MARADP<35%,MARAA<35%.The data showed that antiplatelet therapy could reduce the Maximum aggregation rate.More important,at 3-month follow-up,adequate platelet function inhibition of either MARADP or MARAA wasn't associated with the recurrence of stroke/TIA,but adequate platelet function inhibition of not only MARADP but also MARAA predict lower recurrence of stroke/TIA.(0/121?0.00%?vs.18/459?3.92%,P=0.0188?.Conclusion:The platelet function tested by PL-11 with inductive agents of ADP and AA demonstrated that adequate inhibition of both MARADP and MARAA could predict lower risk of ischemic stroke/TIA recurrence. |