Study On The Effect Of Huoxuehuayu Injection Combined With Aspirin On Platelet Function In Patients With Ischemic Stroke

Objective：Observate the Platelet function、neural function defect degree、TCM disease category score of the combination of Shuxuetong injection,safflower yellow injection, Salviae Miltiorrhizae Ligustrazine Hydrochloride Injection Injection and aspirin in patients with acute ischemic stroke，and explore the effect on platelet function、clinical efficacy、safetyof the combination ofHuoxuehuayu injection and aspirin。Methods：From the Internal medicine-neurology of Wuhan hospital of combination of Traditional Chinese and Western Medicine, we selected120cases of Acute ischemic stroke. According to the simple random method,divided them into three test groups (Shuxuetong group, safflower yellow group, Salviae Miltiorrhizae Ligustrazine Hydrochloride group) and one control group with30patients each. The control group was given conventional western medicine treatment of Acute ischemic stroke, and the three test groups on the basis of respectively with above three kinds of Huoxue Huayu Injection for10consecutive days. Platelet were detected and recorded before treatment and10days after treatment in four groups, The neural function defect score, TCM disease category scor e, platelet aggregation, platelet morphological parameters (platelet count (PLT), mean platelet volume (MPV), platelet hematocrit (PCT), meanplatelet concentration (MPC) etc.) and safety evaluation index (three conventional, liver function, renal function, electrolyte analysis etc.). Andusing SPSS16.O，data were statistieally analyzed.Results：1.The baseline data of1Shuxuetong group, safflower yellow group, Salvia miltiorrhiza Ligustrazine group and the group of four case-control, including gender, age, smoking history, history of hypertension, diabetes, dyslipidemia, history and past history of stroke, no obvious difference.2. cases in the four groups had no significant difference in the maximum aggregation rate of platelet treatment, four groups of patients after treatment were significantly lower (P<0.05), and the three experimental group decreased significantly than that of the control group (P<0.05).PLT and PCT in four cases after treatment, increased platelet morphological parameters, while L-PLT, MPV decreased (P<0.05), L-PLT, MPV in the three experimental groups decreased were superior to the control group (P<0.05).3. four cases of nerve function defect score, TCM disease category score after treatment were significantly improved, a significant difference (P<0.05), and compared with three in the test group were more improved than that in normal control group (P<0.05). The three test groupthe total effective rate of the therapy was better than the control group(P<0.05).4.No significant differences were found in safety evaluation index of examination of4cases in the four groups before treatment (P>0.05) detection, three months after treatment, the experimental group compar ed with the control group had no significant difference (P>0.05); in addition to Shuxuetong group A patients had subcutaneous petechiae, onecases of patients with skin pruritus, showed no serious side effects.5.Display horizontal comparison between5groups, to improve theneurologic impairment, reduce platelet aggregation rate ranked favorably to respectively Shuxuetong group, safflower yellow group, Salvia miltiorrhiza Ligustrazine group, but were better than the control group. There was no obvious change in the safety index of four groups of patients,no serious side effects.Conclusion：The results of this study showed that, between the three groups was compared with Shuxuetong injection combined with aspirin for acuteischemic stroke, can best improve the patient’s neurologic impairment,and the strongest inhibition of platelet aggregation, although there arecases appeared side-effects ecchymosis, skin itching, but for once, andminor, except that no other serious side effects, efficacy safety; safflower yellow injection, Salviae Miltiorrhizae and ligustrazine hydrochloride injection combined with aspirin can also strengthen the aspirin anti-platelet aggregation, can better improve the ischemic stroke impairment, and no obvious side effects occurred in the process, high safety and good. Through the research on preliminary assessment of Shuxuetong injection, safflower yellow injection, Salviae Miltiorrhizae and ligustrazine hydrochloride injection combined with aspirin in the treatment of acute ischemic stroke, clinical curative effect is obviously superior to the singletreatment with aspirin, and did not significantly increase the serious complication such as haemorrhage, clinical curative effect and safety of high.