Effects Of Tanshinone-?_A Sodium Injection Post-Conditioning Combined With Controlled Low Central Venous Pressure On The Hepatic Ischemia-Reperfusion Injury

Objective:To investigate the protective effects of tanshinone-?_A sodium injection post-conditioning combined with controlled low central venous pressure on hepatic ischemia-reperfusionon injury during liver resection and its possible mechanism.Methods:Eighty patients scheduled for liver resection,46 males and 34 females,ASA physical status?or?,were randomly divided into four groups:tanshinone-?_A sodium post-conditioning?group D?,tanshinone-?_A sodium post-conditioning combined with controlled low central venous pressure?CVP 1-5 cm H₂O?group?group DL?,controlled low central venous pressure?CVP 1-5 cm H₂O?group?group L?and control group?group C?that take the static-compound anesthesia and maintained CVP 6-12 cm H₂O,20 in each group.The venous blood samples were draw from internal carotid vein at different time point:pre-occlusion ten minutes?T₀?,post-occlusion 2 h?T₁?,6 h?T₂?,12 h?T₃?,24 h after operation?T₄?,and then detected the levels of NF-?B,ICAM-1,ALT and AST.The MAP,HR and CVP were recorded.Results::Compared with group C and group D,CVP were significantly lower at T₀ and T₁in group L and group DL?P<0.01?.Compared with T₀,levels of NF-?B,ICAM-1,ALT and AST in four group at T₁-T₄ were significantly increased?P<0.01?.Compared with group C,levels of NF-?B,ICAM-1,ALT and AST in group DL,group L and group D at T₁-T₄ were significantly decreased?P<0.05?.Compared with group DL,level of NF-?B,ICAM-1,ALT and AST in group D and group L at T₁-T₄were significantly increased?P<0.01?.Conclusion:Tanshinone-?_A sodium injection post-conditioning combined with controlled low central venous pressure in patients with partial hepatectomy,can reduce the degree of ischemia-reperfusion injury.