| Objective Excavate and sort out the medical records of treating diarrhea in ancient medical books.Summarize the characteristics of its therapeutic methods,Analyze the medication rule.Thus provide a reference for enriching the diagnosis and treatment of diarrhea diseases in modern clinical practice,and offers a literature basis for the development of new drugs related to Chinese medicine.Methods On the basis of consulting and investigating the relevant documents recording medical cases of diarrhea in ancient medical books,with books collected in the library of Zhejiang Institute of traditional Chinese Medicine as the source material,consult representative medical works of diarrhea cases written by medical experts of the past dynasties prior to the late Qing Dynasty(1911).Refer to the large literature book "Collection of Medical cases.",and select the medical cases as the key study object with the relevant cardinal symptom of "diarrhea".Conduct arrangement of document by adopting the document research principles of eliminating the false and preserving the true,removing the coarse and retaining the essential,and making the past serve the present.Through the analysis and review of typical medical cases,summarize the characteristics of the therapeutic methods therein.Collect the prescriptions recorded in the medical cases that conform to the standard of data incorporation.Input such prescriptions in Chinese Medicine inheritance Assistant system Software(V2.0)to establish a data bank of prescriptions treating diarrhea.Make use of frequency statistics,rule analysis,entropy clustering of complex systems and other data excavation methods to find high-frequency drugs,drugs properties,meridian tropism,medicine suits,and so on.Explore the medication rule in treating diarrhea.Analyze and study the statistical results by the software with the method of prescription test.Results ?The great methods of diarrhea treatment in ancient medical books could be classified into eight categories,namely,warm-tonification,eliminating dampness,intestinal clearing,dispelling wind to ventilate the lungs,harmonizing,invigorating Qi for ascending,nourishing Yin,and relieving exterior syndrome.?Complying with the screening criteria of medical cases,a total of 604 prescriptions were collected,involving 277 kinds of traditional Chinese medicine,with a total frequency of 5312 times.?The statistical results showed that:the top five herbs in the treatment of diarrhea were Poria cocos,Atractylodes macrocephala,Glycyrrhiza uralensis,Dried tangerine or orange Peel and Ginseng respectively;The high frequency drugs were classified according to their efficacy as medicines for tonifying deficiency,inducing diuresis and excreting damp,resolving dampness,warming the interior,relieving exterior syndrome,regulating qi,promoting digestion,clearing heat,inducing astringency,etc.;The main property of drug was warming,followed by peaceful and cold;The medicinal flavor was mostly sweet,followed by pungent and bitter;The meridian tropism of the top five kinds of herbs were spleen,stomach,lung,kidney and heart respectively;The medicine suits of Atractylodes macroeephala-Poria cocos was the most common.Conclusions The ancient medical records of diarrhea cases were rich in contents and full of information,wherein,there were many kinds of therapeutic methods.The characteristics of medication rule were obvious,better reflecting the features of treatment and enlightening the thinking of modern clinical diagnosis and treatment of diarrhea.It was of practical significance for improvement of the clinical efficacy of traditional Chinese medicine in the treatment of diarrhea diseases,and would provide important clues for the development of new drugs related to Chinese medicine. |
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