Literature Research And Data Mining Based On Epigastralgia Medical Cases Of Famous Ancient Scholars

Objective The article is to summarize the treatment characteristics and application of classical prescriptions though sorting out the medical cases of epigastralgia of ancient famous scholars,and analyse the law of making formula and description by way of data mining.The experiance from ancient famous experts can broaden the thinking of diagnosis and treatment for treating similar diseases in modern society.Methods 1.Investigating the relevant literature of epigastralgia medical cases recorded in ancient medical books,and taking the library collection of Zhejiang Chinese Medical University and Zhejiang Institute of Traditional Chinese Medicine as the source of material were to collect the works of epigastralgia medical cases written by famous ancient scholars before the late Qing Dynasty(1911).At the same time,medical cases with cardinal symptoms related to epigastralgia were selected as the key object of study by referring to the book“Aggregation of Medical Case”.Analyzing and commenting on typical cases were to summarize the characteristics of its treatment and the application of classical prescriptions through the traditional way of studying the ancient medical cases.2.The data of medical cases was rescreened and normalized.Prescriptions that met inclusion criterions were input to the Chinese Medicine Inheritance assistant system software(V2.5)system.A prescription database for the treatment of epigastralgia was established.Data mining methods such as frequency statistics,rule analysis and entropy clustering of complex system were used to find high-frequency drugs,drug properties,meridian tropism,medicine suits and so on.The statistical results of software that analyzed and studied were used to explore the rule of drug use in the treatment of epigastralgia.Results 1.In ancient Chinese medical books,the therapy of epigastralgia can be claasified into eight categories,liver therapy,warm-tonification,eliminating phlegm,removing blood stasis,dehumidification,nourishing Yin,Xuanjiang method,and removing stagnancy.Commonly uesed classical prescriptions are Xiaojianzhong Decoction,Dajianzhong Decoction,Lizhong Decoction,Lingguizhugan Decoction,Gualou Xiebai Banxia Decoction,Xuanfuhua Decoction,etc.2.There were 339 medical cases which met the criteria,including 400 prescriptions and 304 traditional Chinese medicines.3.Statistics results of the data showed that among the high frequency drugs,the top five drugs was more than 100 times,which were pinellia ternata,poria cocos,orange peel,rhizoma cyperi and licorice.The most frequently used drugs are qi-regulating drugs,followed by tonifying deficiency drugs,cough-relieving,sputum-reducing and asthma-prventing drugs,warm the interior drugs and so on.Warm is the dominant factor in the four properties of drugs,followed by cold one.Acid is the main ingredient of five tastes,followed by bitter one.Mainly channel tropism was attributed to the spleen and stomach,but also closely related to the liver and lung.Pinellia ternata and poria cocos cooccurrenced most frequently.The 11 core drugs include Erchen Decoction,Shaoyao Licorice Decoction,Zuojin Pill and Jinlingzi Powder.21 new prescriptions and 42 core drugs for epigastralgia were found.Conclusion In the treatment of epigastralgia,famous scholars of past dynasties paid attention to the liver therapy,while the application of classical prescriptions mainly focused on Jianzhong and Lizhong.They ofen combined cold and warm drugs or acid and bitter drugs,while followed the prescription rule of mutual promotion and mutual enhancement for epigastralgia treatment.In addition,special attention is paid to the application of drugs for expelling phlegm and drying dampness,which often run through the method of regulating qi.