Esophageal Ning United Western Medicine In The Treatment Of RE With Esophageal Cough Clinical Observation

Object:The purpose of this study is to observe the clinical efficacy of esophageal ning united weatern medicine in treatment of qi-phlegm stagnation syndrome reflux esophagitis with esophageal cough.Objectively evaluate the treatment of reflux esophagitis with esophageal cough in both Chinese medicine theory and clinical research,explore the mechanism of its treatment.Methods:1.From May 2016 to June 2017,Professor Gan Aiping’s specialist outpatient clinic of the Department of Spleen and Stomach Disease of Hubei Provincial Hospital Of TCM.By spud qi-phlegm stagnation syndrome reflux esophagitis with esophageal cough clinical symptoms and Classification quantization table,gastroscopy,chest X-ray,etc.The patients were diagnosed with Chinese and Western medicine and included in 66 cases.They were divided into two groups using the principle of complete randomness and compound treatment control.Finally,they were included in 65 cases,33 cases in the treatment group,and 32 cases in the control group.There was no significant difference(P>0.05)in gender,age,duration of disease and total score of clinical symptoms before treatment between the two groups.2.Treatment group treated with oral esophageal ning and omeprazole enteric capsule,the contrast group treated with omeprazole enterolysis capsule and Moshabili citrate dispersible tablets.The course of treatment in the treatment group and the contrast group was twelve weeks.The patient was referred once every two weeks.Changes in the symptoms and signs were observed and recorded.Observe and record the changes of symptoms and signs of the patient.Conduct a gastroscopy examination before and after treatment,and an examination of safety observation indicators(blood routine,urine routine,fecal routine,liver function,renal function,electrocardiogram).During the treatment,patients should be given a healthy diet and avoid taking other therapeutic drugs related to this disease.3.Refer to"Cough Diagnosis and Treatment(2015)"and"Consultation on Treatment of Gastroesophageal Reflux Disease in TCM(2017)"to determine the main clinical symptoms and quantitative grading criteria.Record the main clinicalsymptoms of each patient before and after treatment(day cough,night cough,acid reflux,poststernal burning or burning pain,chest flank or abdominal distention,obstruction by swallowing,phlegm,reflex belching,mouth dry mouth,stomach craving,hunger,food loss,poor mood)In the case of integrals,review the gastroscope after twelve weeks of treatment to observe the status of esophageal mucosa.Followup after half a year of treatment to understand the recurrence of the disease.4.Statistical analysis methods:All data were analyzed using SPSS21.0 statistical software.Count data were analyzed usingχ~2 test,measurement data were analyzed by t-test,and rank data were tested by rank sum test.Results:After the end of treatment,the clinical efficacy of the two groups was compared.The total effective rate was 90.9%in the treatment group and 84.3%in the contrast group.The clinical effect of treatment group was better than that of control group(P<0.05).Comparing the results of gastroscopy between the two groups,the total effective rate was 87.8%in the treatment group and 84.4%in the contrast group.The efficacy of the two groups was comparable(P>0.05).Comparing the clinical symptom scores of the two groups and t-test,the treatment group was superior to the contrast group in the symptoms of cough,poor mood,obstr uction by swallowing,phlegm,poor appetite.There was a statistical difference(P<0.05).In particular,there were significant differences in night cough and mood depression(P<0.01).Compared to the night cough,there was no significant difference between the two groups in day cough symptoms improvement(P>0.05).After six months of follow-up,the recurrence rate of the treatment group was lower than that of the contrast group,with statistical significance(P<0.05).Conclusion:The results of this study show that the combination of esophageal ning united western medicine in the treatment of qi-phlegm stagnation syndrome reflux esophagitis with esophageal cough has a clear curative effect,the clinical recurrence rate is small and the safety is high.Esophageal ning has an advantage in improving symptoms such as coughing at night,swallowing obstruction or foreign body sensation,phlegm,poor appetite,and poor mood.It has clinical promotion value.