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Predictive Value Of Quantitative Magnetic Resonance Analysis For Arrhythmias In Ischemic Cardiomyopathy

Posted on:2019-06-05Degree:MasterType:Thesis
Country:ChinaCandidate:D L GuoFull Text:PDF
GTID:2334330545487624Subject:Clinical medicine
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Objective:The purpose of this study was to evaluate the predictive value of abnormal ventricular wall motion and late gadolinium-enhanced cardiac magnetic resonance for potential ventricular arrhythmia in patients with ischemic cardiomyopathy by CMR multisequence scanning.To evaluate the correlation between ventricular wall motion,left ventricular ejection fraction(LVEF)and delayed enhancement,and its predictive effect compared with delayed enhancement in order to improve the screening and early prophylactic treatment of patients with ischemic cardiomyopathy prone to malignant arrhythmia.Materials and Methods:Thirty patients with ischemic cardiomyopathy were selected from January 2012 to August 2017.All patients underwent cardiac MRI scan before operation.30 patients with ICM were divided into two groups according to the results of intracavitary electrophysiological examination:group A(with malignant arrhythmia group)and group B(without malignant arrhythmia).The left ventricular wall motion and delayed enhancement were analyzed by the 17 segmental methods recommended by American heart Association for analysis.The MRI images of all patients were analyzed through cvi42 post-processing software to obtain the parameters of left ventricular function and delayed enhancement.After determining the epicardial and endocardial boundaries,we can obtain quantitative information on the wall motion and delayed enhancement of each segment of the left ventricle by determination the right and left ventricular intervention points.Results:According to the criteria of inclusion and exclusion,a total of 30 patients were included in this study.According to the results of EPS,they were divided into two groups:group A(16 cases)with malignant arrhythmia and group B(14 cases)without malignant arrhythmia.Among them,18 cases were male and 12 cases were females,the ratio of male and female was 3:2.The age ranged from 37 to 71 years old,the average age was 54 years old.The average time for CMR examination was 7.68 days.There was no statistical difference in baseline data between the two groups.There was a significant difference between the two groups(p<0.05):the LVEF value of group A was significantly lower than that of group B,while EDV?EDVI?ESV?ESVI of group A were significantly higher than those of group B.Conclusion:1.To some extent,the local left ventricular wall motion decrease,systolic and diastolic function decrease,and myocardial delayed enhancement occurred in patients with ICM.2.The LVEF in patients with arrhythmia after ICM was significantly lower than that in patients without arrhythmia.The number of paradoxical wall motion segments was significantly higher than that of non-malignant arrhythmia group,and the enhancement quality of myocardium was also significantly higher than group B.3.NO.10 segments motion and Myocardial enhancement mass are independent risk factors for predicting arrhythmia in patients with ICM.4.NO.10 segment's motion was positively correlated with LVEF and negatively correlated with LGE.5.In terms of the ability to predict arrhythmias after ICM,the sensibility of ventricular wall motion to was lower than that of LVEF and the specificity was higher than that of LVEF.The sensibility of ventricular wall motion was lower than that of LGE and the specificity was consistent with LGE.
Keywords/Search Tags:Ischemic cardiomyopathy, Malignant ventricular arrhythmia, Wall motion, Late gadolinium-enhanced, Left ventricular ejection fraction
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