| Objective:Reviewing the ancient and modern literature on post-circulatory ischemic vertigo,and based on the theoretical knowledge and clinical experience of tutors in the treatment of the disease,the basic pathogenesis of this disease was hypoxia of liver and kidney,wind-yang upset,and kidney-based Pinggan method was used accordingly.After the treatment of Bushen Pinggan Decoction,the patients were treated with circulating ischemic vertigo.Through standardized clinical trials,evaluate the clinical efficacy of Bushen Pinggan Fang and observe the improvement of the related laboratory test results,and provide theoretical basis and clinical experience for treatment of circulating ischemic vertigo after Bushen Pinggan Therapy.Methods:Following the principle of randomized controlled trials,88 cases of posterior circulation ischemic vertigo were included in the inclusion criteria.Patients were randomly divided into treatment group and control group of 44 cases.The control group was treated with routine Western medicine and the treatment group was treated with Bushen Pinggan Fang on the basis of the control group.Both groups were treated for 2 courses for a total of 8 weeks.The relevant indicators were recorded before and 8 weeks after treatment.Finally,3 patients in the control group and 2 patients in the treatment group were lost due to loss of follow-up.One patient in the control group and 2 patients in the treatment group were excluded due to the rejection of related examinations.A total of 80 patients with posterior circulation ischemic vertigo were completed.The treatment group and the control group each had 40 cases.According to the "post-circulatory ischemic vertigo comprehensive assessment scale" score to assess the comprehensive effect,according to the "Vertigo Kidney Deficiency and Yang Syndrome Syndrome Scale" to assess the efficacy of TCM syndromes.We also calculated scores of the "post-circulatory ischemic vertigo comprehensive assessment scale","divergent rating scale rating system(DARS)," and "dizziness disorder scale screening list(DHI-S)" before and after treatment.To assess the degree of vertigo attack and improve the quality of life.Transcranial Doppler(TCD)was used to detect the Vs’,Vm’,and PI values of bilateral vertebral arteries and basilar arteries,and blood low-density lipoprotein,whole blood hyperviscosity,and fibrinogen levels were measured.The impact of laboratory indicators.In order to investigate the safety of the drug,hematuria and feces were tested before and after treatment for the three major routine,liver and kidney functions,and the adverse reactions during drug administration were observed.Results:The treatment group was cured clinically in 8 cases(20%),markedly effective in 8 cases(20%),effective in 18(45%),and the total effective rate was 85%;in the control group,2 cases were recovered(7.5%),and 6 cases were markedly effective(15%),Effective in 18 cases(45%),with a total effective rate of 62.5%.Comparison of the two groups,Chi-square test,P<0.05.The comprehensive effect of the treatment group was better than that of the control group.Different posterior circulation ischemic vertigo symptom rating scales were used to evaluate the degree of improvement in scores before and after treatment in the two groups and differences between groups.(1)Comparison of post-circulatory ischemic vertigo comprehensive rating scale scores:The scores of each item in the treatment group after treatment were significantly lower than before treatment(P<0.01),indicating the degree of vertigo,duration of vertigo,and seizure frequency,concomitant symptoms and signs Both have significantly improved.The degree of vertigo,duration of vertigo and frequency of seizures after treatment in the control group were lower than those before treatment(P<0.01),but there was no obvious improvement with symptoms and signs(P>0.05).The total scores after treatment were significantly lower than before treatment.(P<0.01),the treatment group decreased more significantly than the control group(P<0.05).(2)Comparison of DARS and DHI-S scores:After treatment,the scores of DARS and DHI-S in the two groups were significantly lower than before treatment(P<0.01),and the decline in the treatment group was greater than that in the control group(P<0.01).Post-circulatory ischemic vertigo:Kidney Deficiency Liver Syndrome Improvement Syndromes:(1)Comparison of the efficacy of two groups of symptoms:The treatment group recovered 2 cases(5%),markedly effective in 10 cases(25%),and effective in 23 cases(57.5%)The total effective rate was 87.5%;the control group recovered 0 cases,markedly improved in 5 cases(12.5%),effective in 20 cases(50%),and the total effective rate was 62.5%.The two groups were compared by chi-square test,P<0.05.(2)Comparison of scores of two groups of syndromes:treatment group(7.55±3.16)points after treatment,significantly lower than before treatment(17.8±4.24)points;after treatment group(10.8±3.65)points,significantly lower than before treatment(17.3±2.8)points,P<0.01;after treatment,P<0.01,the treatment group was superior to the control group.The treatment group improved more significantly than the control group in dizziness/dizziness,lumbar acid/facial tenderness,facial warming/flushing,forgetfulness,tinnitus/brain noise(P<0.05).Laboratory test results:(1)Comparison of Vs’,Vm’,and PI values in the vertebral artery and basilar artery between the two groups:After treatment,deviations of bilateral vertebral artery and basilar artery blood flow velocity were significantly improved compared with those before treatment,P<0.01.After treatment,the left vertebral artery PI value,Vs’,Vm’ and basilar artery Vm’ were significantly improved in the treatment group compared with the control group(P<0.05),and the abnormal rate in the treatment group was significantly lower than that in the control group(P<0.05).(2)Comparison of physical and chemical indicators of improvement in the two groups after the circulatory ischemia:the two groups of low-density lipoproteins,high blood viscosity high cut,fibrinogen treatment were significantly reduced(P<0.01);between the groups,the treatment group fiber The degree of proteoglycan decline was greater than that of the control group(P<0.05).conclusion:The addition of Bushen Pinggan Decoction on the basis of routine treatment of Western medicine improves the clinical curative effect,improves the degree of dizziness,shortens the duration of dizziness,reduces the number of dizziness episodes,and reduces the accompanying symptoms and signs of dizziness.It is superior to Western medicine alone in the conventional treatment methods;it can exert the overall treatment advantages of traditional Chinese medicine and reduce the symptoms of Kidney Deficiency and Liver Syndrome,such as leg weakness,facial warming,forgetfulness,and tinnitus,indicating that the method of tonifying the kidney and calming liver is to treat post-circulatory ischemic vertigo.Useful ways.The results of laboratory tests showed that Bushen Pinggan Fang can effectively improve the blood flow velocity of the vertebral-basal artery,reduce the plasma fibrinogen content,and prevent the onset of post-circulatory ischemic vertigo.After treatment of Bushen Pinggan Decoction,no adverse reactions were found in circulating ischemic vertigo,and the safety was good.It is worthy of clinical application. |
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