Analysis Of The Risk Factors For Acute Phase Epileptic Seizures In Patients With Herpes Simplex Encephalitis

Analysis of the risk factors for acute phase epileptic seizures in patients with herpes simplex encephalitisHerpes simplex virus encephalitis(HSE)is a common pathogen of viral encephalitis and patients with 40-60% may the most complicated with epilepsy during the acute phase.The incidence of epileptic encephalitis in the acute phase of the onset of the seizure increased by 22 times than that of the unattacked patients,and the first 5 years of epilepsy after viral encephalitis at highest risk.Isolation of the virus and cerebrospinal fluid and brain tissue to detect specific nucleic acid is the gold standard for the diagnosis of viral encephalitis,but only less than 30-40% cases of encephalitis can give the etiological diagnosis,and is not widely used in clinical diagnosis and treatment of Chinese,now is the main basis for the clinical diagnosis of patients and clinical examination performance.At present,clinical diagnosis is mainly based on cerebrospinal fluid(CSF),electroencephalogram(EEG),imaging examination and clinical features.Timely treatment of controllable factors such as epilepsy can improve long-term clinical prognosis.Objective:Explore the risk factors of secondary epilepsy in acute stage of herpes simplex encephalitis,to provide a theoretical basis for evaluating prognosis of encephalitis,and to guide clinical medication to prevent epilepsy.Method:From January 2016 to January 2018,a total of 60 patients with clinically diagnosed herpes simplex encephalitis,who were admitted to Jiangxi People’s Hospital,were randomly divided into 2 groups according to whether they had seizures in acute phase.Collect all the patients with herpes simplex virus encephalitis clinical features(including age,gender,history,mode of onset,clinical manifestations,Glass coma scale,intracranial pressure),laboratory tests(blood routine examination,cerebrospinal fluid routine biochemical and cytological,blood or cerebrospinal fluid antibodies)and imaging(Head CT.The head of MRI),EEG,statistics of all the data and analysis,the research of herpes simplex virus encephalitis acute risk factors of epileptic seizures.Result:This study shows that abnormal electroencephalogram and abnormal headMRI are the risk factors of epileptic seizures in herpes simplex virus.Therefore,it is very important in the acute period of viral encephalitis to give timely antiviral treatment to patients with epilepsy.Clinical features(including age,sex,past history,form of onset,clinical manifestation,intracranial pressure,maximum body temperature,level of consciousness,GCS evaluation),and laboratory examination(blood routine,electrolysis)in 60 patients with herpes simplex encephalitis in patients with herpes simplex encephalitis(including age,sex,past history,form of onset,clinical manifestation,intracranial pressure),and the clinical features of patients with herpes simplex encephalitis were diagnosed.The changes in quality,cerebrospinal fluid routine,biochemical and cytological,blood or cerebrospinal fluid antibody test),imaging(CT,MRI),electroencephalogram and other changes were compared.The results were found in two groups of patients "temperature,headache,GCS score,blood leukocyte,blood sodium,total number of leukocytes in the cerebrospinal fluid,abnormal EEG,difference.MRI is a risk factor for epilepsy in patients with herpes simplex encephalitis.On the basis of single factor analysis,in order to further determine the effect and extent of influence factors in the patients with herpes simplex viral encephalitis,Logistic regression analysis was carried out with the occurrence of epilepsy as a dependent variable.The results showed that the variables of statistical significance into the regression equation were abnormal electroencephalography and the head of the regression equation.Cranial MRI abnormalities(P<0.05).Conclusion:In summary,epilepsy is more common in patients with herpes simplex virus encephalitis,abnormal electroencephalogram and abnormal head MRI are the risk factors of epilepsy,and most of the patients with epilepsy in the control of encephalitis and antiepileptic drugs can be improved and controlled.Therefore,timely antiviral treatment and close observation of high-risk groups can effectively control the progress of epilepsy after encephalitis.