Study On The Gadolinium-based Contrast Agent Accumulates In The Brain And Its Influence Factors

ObjectiveTo explore the model of Gadolinium-based Contrast Agent deposition in the Brain and its influence factors.MethodA group of 39 patients who had undergone at least 3 contrast-enhanced brain MRI examinations were analyzed retrospectively.Select right globus pallidus,right thalamus,right dentate nucleus,pons,and white matter of right frontal lobe as five region of interests(ROI),the mean signal intensitys(SI)of the ROI were measured on unenhanced T1-weighted images,include every scan.The globus pallidus-to-white matter SI ratio was calculated by dividing the SI in the globus pallidus by that in the white matter,the thalamus-to-white matter SI ratio was calculated by dividing the SI in the thalamus by that in the white matter,the dentate nucleus-to-white matter SI ratio was calculated by dividing the SI in the dentate nucleus by that in the white matter,and the pons-to-white matter SI ratio was calculated by dividing the SI in the pons by that in the white matter.T tests were employed to examine if the SI ratio variation between the last scan and first scan differed from 0.Spearman correlation analysis was used to analyze the correlation between signal intensity ratio,enhancement times and other clinical factors.ResultsThe signal intensity ratio of dentate nucleus-to-white matter of the last MRI scan was significantly higher than that of the first MRI scan(1.113±0.136 and 1.014±0.096,P<0.01).The signal intensity ratio differences between the last and first MRI scan of the globus pallidus-to-white matter,the thalamus-to-white matter,and the pons-to-white matter did not differ significantly from 0(1.064±0.116 and 1.017±0.104,P =0.054;1.016±0.100 and 0.977±0.096,P=0.064;1.004±0.096 and 0.974±0.090,P =0.097).The dentate nucleus-to-white matter signal intensity ratio showed a significant correlation only with the number of previous gadolinium-based contrast material administrations (r=0.329,P =0.041),but not with the other factors such as age,gender,chief diagnose,treatment,and history of diabetes.ConclusionsThis study found that multiple injection of gadolinium-based contrast agent could lead to high signal intensity in the dentate nucleus on unenhanced T1-weighted images,and the degree of increase was positively correlated with the number of MRI enhanced scan.It indicated that gadolinium contrast agent deposition;age,gender,disease and other factors had no significant effect on gadolinium deposition.