| Objective To unstandard the incidence of prediabetes and diabetes in Jinchang cohort,and to explore the factors influencing the incidence of prediabetes and diabetes,so as to provide scientific basis for the prevention and treatment of diabetes.Methods Based on Jinchang cohort's follow-up population,a prospective cohort study was used to analyze the incidences of prediabetes and diabetes in this study.And the nested-case control study was used to explore the influencing factors on the incidence of prediabetes and diabetes,and calculate the odds ratio(OR)and 95% confidence intervals(CI).The interaction additive model was used to evaluate whether there would be an additive interaction between two factors.Results 1.The incidence of prediabetes in Jinchang cohort was 20.16%(21.67% for men and 18.05% for women),the incidence density was 9250 per 100,000 person-years(10083 pre 100,000 person-years for men and 8120 per 100,000 person-years for women).The incidence of diabetes was 3.89%(4.46% for men and 3.02% for women),the incidence density was 1763 per 100,000 person-years(2039 per 100,000 person-years for men and 1353 per 100,000 person-years for women),the incidence of diabetes in people with normal fasting plasma glucose at baseline was 1.47%(1.79% for men and 1.03% for women),the incidence density was 545 per 100,000 person-years(664 per 100,000 person-years for men and 385 per 100,000 person-years for women),the incidence of diabetes in people with prediabetes at baseline was 15.92%(16.03% for men and 15.69% for women),the incidence density was 6920 per 100,000 person-years(6949 per 100,000 person-years for men and 6859 per 100,000 person-years for women).2.With the increase of age,BMI,blood pressure,serum TC,TG,LDL-C and uric acid,the incidence of prediabetes in Jinchang cohort showed an upward trend(Ptrend<0.05).And the incidence of prediabetes in Jinchang cohort decreased with the increase of serum HDL-C(Ptrend<0.05).In addition,the incidence of prediabetes was higher in high-fat diets than non-high-fat diets(P < 0.05).3.With the increase of age,BMI,blood pressure,serum TG and uric acid,the incidences of diabetes in people with normal fasting plasma glucose and prediabetes at baseline were all rising(Ptrend<0.05).And with the increase of serum of HDL-C,the incidences of diabetes were all desreasing(Ptrend<0.05).4.There was a positive additive interaction between hypertension and hyperuricemia on the development of prediabetes in Jinchang cohort.When hypertension and hyperuricemia were co-existing,the risk of prediabetes(OR,95%CI)in total population,male and female population were 4.81(3.72-6.20),4.68(3.54-6.19),6.39(3.34-12.22)respectively.In addition,high-fat diets had positive additive interaction with overweight/obesity and hypertension on the development of prediabetes in males respectively.And hypertriglyceridemia had positive additive interaction with overweight/obesity,hypertension,hypercholesterolemia and hyperuricemia on the development of prediabetes in males respectively.Also High-fat diets had positive additive interaction with hypercholesterolemia,hypertriglyceridemia on the development of prediabetes in females respectively.And overweight/obesity had positive additive interaction with hypertension,hyperuricemia,family history of diabetes on the development of prediabetes in females respectively.5.There was a positive additive interaction between hypertriglyceridemia and hyperuricemia on the development of diabetes in people with normal fasting plasma glucose at baseline in Jinchang cohort.When hyperuricemia and hyperuricemia were co-existing,the risk of diabetes(OR,95%CI)in total population,male and female population were 7.13(4.70-10.83),8.42(5.13-13.83)and 7.09(2.94-17.14).In addition,overweight/obesity,hypertension,hypertriglyceridemia,low HDL-C hyperlipidemia and hyperuricemia had positive additive interaction on the development of diabetes in males who are with normal fasting plasma glucose at baseline.Also there was a positive additive interaction between overweight/obesity and low HDL-C hyperlipidemia on the development of diabetes in females with normal fastin plasma glucose ant baseline.6.There was a positive additive interaction between overweight/obesity and hypertension on the development of diabetes in people with prediabetes at baseline in Jinchang cohort.When overweight/obesity and hypertension were co-existing,the risk of diabetes(OR,95%CI)in total population,male and female population were 4.93(3.74-6.52)?4.11(2.95-5.73)?7.65(4.54-12.87)respectively.In addition,there was a positive additive interaction between overweight/obesity and hyperuricemia on the development of diabetes in men with prediabetes at baseline,while family history of diabetes had positive additive interaction with hypertension,hypertriglyceridemia,hyperuricemia respectively,and hypertension had positive additive interaction with hypertriglyceridemia,hyperuricemia respectively on the development of diabetes in women with prediabetes at baseline in Jinchang cohort.Conclusion 1.Compared with domestic and foreign studies,the incidences of prediabetes and diabetes in Jinchang cohort are at a relatively high level.2.High-fat diet,overweight/obesity,hypertension,hypercholesterolemia,hypertriglyceridemia and family history of diabetes are the risk factors of prediabetes in Jinchang cohort.Furthermore,there is a positive additive interaction between hypertension and hyperuricemia on the development of prediabetes.3.Overweight/obesity,hypertension,hypertriglyceridemia,hyperuricemia and family history of diabetes can promote the rapid development of diabetes in people with prediabetes at baseline in Jinchang Cohort.Furthermore,there is a positive interaction between overweight/obesity and hypertension on the development of diabetes. |
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