The Expression Of Plasma Soluble Receptor For Advanced Glycation End Products In Adult Patients With Bronchial Asthma And Its Correlation

Objective:The aims of this study were to investigate the expression of soluble receptor for advanced glycation end products（sRAGE）and to evaluate its relationship with interleukin-8（IL-8）,first-second forced expiratory volume（FEV1）,fractional exhaled ni-tric oxide（Fe NO）and asthma Control Test（ACT）in patients with adult asthma（asthma）.At the same time,the specificity and sensitivity of sRAGE in the diagnosis of adult asthma were analyzed by receiver operating characteristic（ROC）curve.Methods:Sixty-eight cases of patients with adult asthma were recruited in this study from October 2016 to March 2017 in Gansu Provincial Hospital.The patients were divided into acute group（n=33cases）,chronic group（n=35 cases）and 20 healthy adults were enrolled as the control group.The levels of sRAGE and IL-8 in the serum of each group were measured by enzyme-linked immunosorbent assay（ELASA）,and FEV1 and Fe NO were routinely detected.The sRAGE correlation with and IL-8,FEV1,ACT and Fe NO was analyzed.Results:1.The levels of sRAGE,ACT and FEV1 in asthmatic patients were significantly lower than those in the control group（p<0.05）.The levels of sRAGE,ACTand FEV1 in the patients with the acute group were significantly lower than those in the chronic group（p<0.05）.The levels of IL-8 in asthmatic patients were significantly higher than those in the control group（p<0.05）.The levels of IL-8 in the acute group were significantly higher than those in the chronic group（p<0.05）.The level of Fe NO in the acute group was significantly higher than that in patients with chronic and control（p<0.05）.There was no significantdifferenceinFe NOlevelbetweenthechronicandcontrol group（p>0.05）.2.Pearson correlation analysis showed that sRAGE was negatively correlated with IL-8 and Fe NO（r=-0.834;-0.503,p<0.01）,and positively correlated with FEV1and ACT（r=0.903;0.685,p<0.01）.3.The sensitivity and specificity of sRAGE for the diagnosis of adult asthma were based on ROC curves.The cut-off value was 69.75 with the maximum Yoodendex=0.64.The sensitivity and specificity of sRAGE in adult asthma were95%,69.1%.The area under ROC curve of sRAGE was 0.857.Conclusion:Changes in sRAGE expression as the condition of bronchial asthma aggravates,the more sRAGE consumed,the plasma concentration of sRAGE decreases accordingly.Pearson correlation analysis showed that sRAGE was negatively correlated with IL-8 and Fe NO,and positively correlated with FEV₁and ACT.Therefore,sRAGE can provide a new reference index for asthma diagnosis.