The Serum Vitronectin Levels In Adult Glioma And Its Clinical Significance

Objective: To examine the serum vitronection(VTN)level in adult glioma patients and discuss its clinical significance.Methods: The serum VTN level of 26 cases of gliomas(grade ? 10,grade ? 12,grade ? 4),20 cases of brain tumors other than gliomas,18 cases of cerebral trauma patients and 20 cases of healthy controls was measured by enzyme linked immunosorbent assay(ELISA).Results: Serum VTN levels in glioma patients have nothing to do with gender and age(P>0.05).Serum VTN level in healthy controls,brain tumors other than gliomas and craniocerebral trauma patients was significantly lower than that in gliomas(P<0.05).Serum VTN level in high-grade gliomas(including WHOIII&IV)was significantly higher than that in low-grade gliomas(including WHOII)(P < 0.05).Comparison between control groups: Compared with healthy controls,there was no statistical difference in serum VTN levels between brain tumors other than glioma patients and craniocerebral trauma patients(P>0.05);There was a difference between brain tumor group and craniocerebral trauma group,but there was no statistical significance(P>0.05).Conclusion: Serum VTN has the potential to be a promising diagnostic biomarker for glioma,it can be used for the auxiliary diagnosis of glioma.At the same time,serum VTN can be used as an indicator to evaluate the grade of glioma.