A Resting-state FMRI Study On Impulsive Decision-making Based On Food Choice

The trends of overweight and obesity are increasing in today world,no matter adults or children.World Health Organization WHO points out that obesity and overweight are one of the most serious public health problems,today.Growing overweight groups are threatened by more and more chronic diseases.Although a large part of obesity is affected by genes,over the past two decades of researches have found that the growing role of obesity and the environment could not be overlooked.The rapid growth in recent decades is extremely relevant to our social development to form an obesogenic environment.Such as people's activities are limited,high-fat high-sugar and high-energy food availability.Of course,in addition there are some psychological factors which would lead to overeat.Individual differences in reward sensitivity and impulsivity may be able to predict food preferences and eating,and the diet pattern is deeply rooted in today's society,such as high-energy,high-fat foods that have proven to be sensitive to brain sensitivity and have an important ro le in impulsive control system.One of the important factors is the impulsivity of choice food.Impulsivity in eating behavior could be regarded as eating driven by the immediate rewards despite the delayed negative consequences.Increasing animal models as well as brain imaging evidence among human,in the reinforcement learning frame,suggests an association between substance-related decisional impulsivity/obesity and decreased function of dorsal striatum,which could be underpinned by the decreased sensitivity to learning cues and rewards in the dorsal striatum.However,the resting-state intrinsic functional organization of the dorsal striatum underlying food-related decisional impulsivity remains unknown.To address this issue,we used resting-state functional MRI(fs-fMRI)to measure brain activity among human adults.A total of 79 female subjects were selected,aged 17-27 years,with an average age of 20.59.BMI between 15.56-28.94.The experimental material is 170 different food pictures including 85 high-energy food pictures and 85 low-energy food pictures.We used the resting magnetic resonance to examine the brain activity of adult women.We also asked the subjects to carry out the food assessment task.In the food assessment task,the subjects asked them to ask the subjective taste of the food according to their subjective feeling very much Like the assessment of their long-term consumption of this food on the health of the objective assessment,the extent of very unhealthy to very healthy,and finally from ten pictures(five high-energy and five low-energy food pictures)to select them Each in the taste and health as a neutral picture as a reference picture,and then in the decision-making task so that they will show the picture and the reference to the food picture comparison to choose to eat the reference food or food presented.The results of the study show that only the decision-making intensity of high-energy food is related to the impulse decision of food,and the impulse decision is not related to the decision-making intensity of low-energy food.Because the decision-making intensity of high-energy food was positively correlated with the impulse scale BIS-11,it was also significantly correlated with the DEBQ-EX subscale.The results of resting magnetic resonance(MRI)show that the higher the degree of spontaneous local consistency of the dorsal striatum,especially the dorsal caudate nucleus,and the higher risk of food-related impulses,The spontaneous local consistency of the Re Ho value is higher.This result may indicate that the reaction of the caudate nucleus is related to impulses.Dorsal striatum(caudate nucleus)Sensory passivation of reward rewards in highly impulsive individuals makes it easier for them to ignore the unfavorable results that the reward may bring.In view of the important role of the wedge in visual attention and the basic stages of visual processing,our results further confirm that individuals who are impulsive to food decision making are more likely to pay attention to or maintain interest in delicious high-energy foods and show Food reward is expected.In the subsequent study of the functional connection,we found the food-related impulsive decision with the double-sided wedge and caudate nucleus as the seed point.The higher the strength of the caudate nucleus and the shell nucleus was lower.This result reveals the transition from target-directed behavior to habitual behavior in high-impulsive decision-making individuals associated with food selection.The functional connectivity of the dorsal caudate nucleus to the left orbital frontal cortex was positively correlated with the decision-making intensity of the high-energy food image.This may be an increase in the internal integration of the dorsal caudate nucleus and the lateral orbital frontal cortex,and this increase in the function helps to encode the reward value of the delicious food and exhibits a highly automated nature.There was a significant positive correlation between the left wedge and the right hippocampus and the decision of high energy food.The higher the impulse for food selection,the stronger the functional connection strength of the right side of the wedge to the right side of the auxiliary motor area.This shows that food selection of highly impulsive individuals in the visual network with sensory motor networks is highly sensitive.In the study,it was found that the higher the rate of BMI changes and the lower the functional connectivity of the dorsal striatum(caudate nucleus)and the crust.This result may reveal a decrease in the sensitivity of the dorsal caudate nucleus to the reward signal in the decision,along with the behavior of the target-directed behavior(mainly regulated by the dorsal caudate nucleus)to the habitual behavior(mainly regulated by the shell and nucleus)The change is related to the increase in future weight and the enhancement of impulses.In conclusion,this study broadens our understanding of the neural basis of food-related impulsive decisions in resting states a nd provides evidence of biomarkers for future weight gain.