Synthesis And Properties Of Metal Ruthenium Complexes With Near-infrared Absorption

Due to larger Stokes shift?high quantum yield?long lifetime?light stability,the absorption spectrum and emission spectrum of the metal iridium complexes can be regulated by modification and replacement of the ligand.Therefore metal iridium complexes are widely used in fluorescent probes,dual-mode imaging.Considering the heavy atom effect of iridium,the transition from triplet oxygen to singlet oxygen can be realized.Therefore,metal iridium complex also attracts great attention in photodynamic therapy.However,the absorption spectra of the vast majority of metal iridium complexes are still in the UV-visible region and do not meet the 600-900 nm bio-light zone required for the treatment,which restrict the application of the metal iridium complexes in biological diagnosis and treatment.With highly conjugated electron systems,phthalocyanines have strong absorption and special thermochemical stability in near-infrared visible regions.In particular,their photophysical and redox properties can be adjusted by selecting metal centers or peripheral substituents.Therefore,it has become a kind of molecular material with unique electronic and physical and chemical properties.The phthalocyanine iridium complex is expected to be used for near infrared light and heat,photodynamic therapy by using the heavy atom effect of metal Ir(III)and the near infrared absorption of phthalocyanine.In this paper,several metal iridium phthalocyanine complexes with near-infrared absorption were designed and synthesized.Based on the study of absorption spectra,the properties of photothermal and singlet oxygen in solution were discussed.The specific contents included the following two aspects :1.Synthesis,structure and properties of protonated iridium phthalocyanine complexesThe protonated metal iridium phthalocyanine complex is synthesized in one step by introducing the electron groups to increase the basicity of meso sites.The crystal structure characterization further confirmed that the protonated metal iridium phthalocyanine complex had a completely planar structure.The photothermal conversion efficiency of the complex is ~ 24%.Comparing with the zinc phthalocyanine,the photothermal stability of the iridium phthalocyanine complex is obviously improved.With DPBF as singlet oxygen indicator,protonated phthalocyanine iridium complex has high singlet oxygen production ability at 808 nm steady state laser.The complex has higher singlet oxygen production efficiency than zinc phthalocyanine.2.Synthesis,Characterization and Spectroscopic Studies of Metal Iridium Phthalocyanine ComplexesThe effects of different conjugation levels on the absorption spectra of metal iridium complexes were studied.The effects of different degree of conjugation on the absorption spectra of metal iridium complexes were studied.The protonated metal iridium complexes were coordinated with ligands which have different axial coordination ability like pyridine(Py),N,N-dimethyltetramethylpyridine(DMAP)to obtain three different metal iridium phthalocyanine.The effects of axial ligands with different electron-donating abilities on the metal iridium phthalocyanine complexes were studied.