Synthesis And Crystal Form Of Moxifloxacin Hydrochloride

Moxifloxacin hydrochloride,chemically known as 1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0.]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid.It is a fourth-generation synthetic fluoroquinolone broad spectr-um antibacterial drug which can be used to treat various types of infections,such as chronic bronchitis,chronic sinusitis,community-acquired pneumonia,sk-in and soft tissue infections.As a new antiseptic drug,moxifloxacin hydrochl-oride has great market potential and research value.The present invention provides a simple,safe and cost effective process,which produces moxifloxacin hydrochloride with high product yield and quality.The method comprises reacting 1-cyclopropyl-8-methoxy-6,7-difluoro-1,4-dihydro-4-o-xo-3-quinolinic acid with(S,S)-2,8-diazabicyclo[4.3.0]nonane to obtain moxifloxacin,reacting moxifloxacin with hydrochloric acid and crystallize.The sample was analyzed by elemental analysis(EA),nuclear magnetic resonance(NMR),mass spectrometry(MS),fourier transform infrared spectroscopy(FTIR),differential scanning calorimetry(DSC),thermogravimetric analyzer(TG)and X-ray powder diffraction(XRD).The crystal structure forms of moxifloxacin hy-drochloride has been disclosed and characterized by XRD.The results of the research provide some basis for the production of moxi-floxacin hydrochloride.