Effect Of Huxin Tongluo Fang Concentrated Pill On Serum OX-LDL, TNF-α And IL-6 In Patients With Stable Angina Pectoris And Qi Deficiency And Blood Stasis Syndrome

Objective:To study the clinical effect of, TNF-α, IL-6 and OX-LDL levels in patients with stable angina pectoris of qi deficiency and blood stasis syndrome treated by the concentrated pill of Huxintongluo.Methods:60 patients who conform the diagnosis and exclusion criteria,which in accordance with the principle of randomized allocation, divided into treatment group and control group with 30 cases in each group. Patients in the two groups in terms of gender, age, course of disease, severity of disease were showed no significant difference (P> 0.05). Between the two groups with Qi can be compared. The treatment group was given conventional western medicine treatment, the control group in the treatment group based on the use of concentrated pill of Huxintongluo, two groups of treatment were 4 weeks. Observe the two groups of patients before and after treatment of TCM syndrome points, Frequency, duration, and glyceryl trinitrate usage in patients with angina pectoris,angina symptoms, TCM syndrome efficacy, serum OX-LDL, TNF-α IL-6 levels.Results:1. TCM syndrome points of the two groups are effective, after treatment, the difference between the two groups has statistical significance.2. After treatment in the two groups of angina pectoris seizure frequency, duration, glyceryl trinitrate used amount and curative effect of TCM syndrome of two group were compared with those before treatment reduced, at the same time, the treatment group after treatment in the chest pain, chest pain, palpitations, shortness of breath, God fatigue fatigue symptom scores decreased compared with the control group, the difference is statistically significant (P< 0.05) and after treatment in the treatment group than in the control group improved significantly(P< 0.05).3. The serum levels of OX-LDL, TNF-α and IL-6 were changed in the two groups, but the curative effect of the treatment group was better than that of the control group (P< 0.05).4. Treatment group after treatment, the clinical efficacy, TCM symptoms were better than the control group, the difference was statistically significant (P< 0.05).5.No adverse events occurred in the two groups during the treatment period.Conclusions:1. The serum levels of OX-LDL, TNF-a and IL-6 were increased in patients with stable angina pectoris of qi deficiency and blood stasis syndrome. After drug treatment, all patients were decreased, which indicated that OX-LDL, TNF-a and IL-6 were abnormal in the pathogenesis of stable angina pectoris. 2.The concentrated pill of Huxintongluo can improve the stability of angina pectoris in patients with traditional Chinese medicine syndrome score, reduce the frequency of angina attacks, duration, glyceryl trinitrate usage, reduce the serum levels of OX-LDL, TNF-a and IL-6. All of this maybe the effect mechanism of the concentrated pill of protecting the heart and collaterals to the stability of angina pectoris.3 It is safe to treat with The concentrated pill of Huxintongluo.