Based On Association Rules And Experimental Research, This Paper Discusses The Rule And Mechanism Of The Treatment Of Nephrotic Syndrome By Chief Physician Zhang Wei

Nephrotic syndrome is one of the common performances of glomerulus disease. Its greatest feature is excess proteinuria (≥3.5g/d) with albuminemi a (≤30g/L), and it always has the performance of edema and hyperlipemia. Proteinuria and low albuminemia are also major dangerous factors of nephr otic syndrome. There are inflammatory/toxic substances in excess proteinuria. Those substances can manifest nephrotoxicity through various mechanisms. Reduce proteinuria is one of the objectives of treating nephrotic syndrome. This paper makes the discussions and analysis from three aspects:literature review, clinical research and experience study. The clinical research, based on association rules, discusses the mentor’s drug using regulations for treati-ng nephrotic syndrome; experience study compares the formula "JiaweiHuan-gqiChifengTang", which is the agreement prescription of proteinuria’s treatm-ent determined by the rules of treatment "YiqiHuoxueQufeng",mainly obse-rving the 24-hour urinary protein quantitative, to test and verify the effect of "Jiaweihuangqichifengtang" for treating proteinuria and to explore its po-ssible action mechanism through measuring the expressions of kidney tissu-e’s COX-1 and COX-2.1.Literature review:The research progress of nephrotic syndrome’s treatment by Chinese medicine.2.Clinical research:Collecting 95 subjects with nephrotic syndrome.140 examine times, based on association rule’s Apriori arithmetic, applying statistics software SPSS 18.0 and SPSS Clementine 11.1 to make statistic dispose and data mining, setting the minimal support at 10%, the minimal confidence at 60%. the paper makes a association rule analysis to the medicine to medicine of the nephrotic syndrome’s treatment of the mentor and makes a frequency statistics to conclude and understand systematacially the mentor’s drug using rules and train of thought.3.Experience study:JiaweiHuangqiChifengTang’s influence to proteinuria and nephridial tissue’s COX-1 and COX-2 of rats with Adriamycin nephropathy.Objective:Study JiaweiHuangqiChifengTang’s influence to proteinuria and nephridial tissue’s COX-1 and COX-2 of rats with Adriamycin nephropathy.Methods:Make rats models with adriamycin kidney disease by intravenous injecting adriamycin to the rats through tail, and then give the rats of JiaweiHuangqiChifengTang group and Prednisone group lavages respectively. At the end of the sixth week of the experiment, collect 24hours urine and calculate the 24 -hour urinary protein quantitative. After reserving the urine, maintain the kidney tissue’s specimen, using western blot method to measure COX-1 and COX-2’s protein expression. Take photos of the color development membrane or negative, and make the Gray Analysis of the images by Lab Works.Results:(1). Comparing with the model group, the 24 -hour urinary protein quantitative of JiaweiHuangqiChifengTang group and Prednisone group both decrease, P<0.01, having the Statistical differences; the 24 -hour urinary protein quantitative of JiaweiHuangqiChifengTang group and Prednisone group stay in a similar level, having no Statistical differences (P>0.05)(2). Analyzing COX-1 and COX-2:comparing with the model group, the gray value of kidney tissue’s COX-1 of Prednisone group increase obviously (P<.01), and the gray value of kidney tissue’s COX-1 of JiaweiHuangqiChifengTang group is relatively high (P>0.05). The expressions the gray value are broad stripe, high density and deep color. While kidney tissue’s COX-2 of the two groups both decrease obviously (P<0.01), expressing as narrow stripe, low density and light color. The gray value of kidney tissues’COX-1 of Prednisone group is a little higher than the JiaweiHuangqiChifengTang group, but there is no obvious differences (P>0.05). However, the gray value of kidney tissues’COX-2 of the JiaweiHuangqiChifengTang group is much lower than the Prednisone group (p<0.05)(3). Negative correlation of COX-1 and COX-2Conclusion:JiaweiHuangqiChifengTang can decrease proteinuria of rats with adriamycin kidney disease obviously. And it can enhance the COX-1’s level of kidney tissue and restrain the expression of COX-2. It has a positive influence to delay the development of glomerular sclerosis through renovating kidney tissues’ damage, improving kidney tissues’normal physiological function, lighting the inflammatory response and improving renal interstitium’s fibrosis.