Analysis Of Clinical And Pathogenic Characteristics Of Hand, Foot And Mouth Disease In Qingdao Women And Children's Hospital From 2013 To 2015

Objective: To study the epidemiology and etiology characteristics of hand-foot-mouth disease(HFMD) from 2013 to 2015 in Qingdao women and children's hospital, as to develop scientific basis of prevention and control of the disease.Methods: Clinical data of HFMD in Qingdao women and children`s hospital from Jan 2013 to Dec 2015 were collected and analyzed.Correlation between clinical data and the disease were analyzed.The enterovirus nucleic acid was extracted from pharyngeal swab specimens of HFMD and was determined by real time PCR. T lymphocyte subsets in peripheral blood were detected by the flow cytometry.Results:A total of 17532 cases with HFMD were confirmed from 2013 to 2015, mostly represented by children under 5 years old accounting for 92.65%, 10714 cases were male including 9666 mild cases, 1048 severe cases, 6818 cases were female, including 6158 mild cases and 633 severe cases. Scattered children were in the majority account for 82.15%(14403/17532),while childcare children were 15.20%(2664/17532) and primary school students were 2.61%(457/17532). HFMD were reported throughout the year and prevalent between June and August each year.EV71(35.83%) and Cox A16(17.22%) were the predominant pathogens verified by real time PCR.The proportion of severe cases also increased gradually with the delaying admission time. In addition, significant decrease was observed in all severe patients in the ratio of CD4/CD8.Conclusions: The increasing cases of HFMD present a seasonal variation and population feature in our hospital. EV71 and Cox A16 were the major etiologic agents of HFMD. More attention of HFMD prevention and control measures should be given to scattered children under 5 years old.