Therapeutic Effect Of Qirong Jianshen Pill Combined With Alendronate Sodium On Senile Osteoporosis With Kidney-yang Deficiency

[Objective]This study was to analyze the changes of clinical symptoms,signs,bone mineral density and bone metabolic index of elderly patients with osteoporosis treated with Cistanche des Kuan Shen Pills combined with alendronate sodium in the treatment of Kidney-Yang Deficiency Syndrome.Rongjian Shenwan.with alendronate sodium in the treatment of kidney-yang deficiency of osteoporosis clinical efficacy and safety of the compound for the medical bed to provide a theoretical basis for the bed,the rich age of osteoporosis treatment method.[Methods]A randomized controlled trial was conducted in 300 consecutive patients with senile osteoporosis.The patients were divided into three groups according to different prescriptions.The treatment time was 12 weeks.A group of Cistanche Kidney Pill 2 times a day,each time a 9g with alendronate once a day,each one 10mg,B group of alendronate once a day,each 1 Omg,C group of Cistanche Jianshen pills twice a day,each one 9g.The serum levels of BGP,serum ICTP,BMD and serum phosphorus were measured before and after treatment in the three groups before and after the treatment.The serum levels of BGP,,The level of alkaline phosphatase,the ratio of urinary calcium/creatinine,the number of primary and secondary syndromes of kidney-yang deficiency,the score of syndrome of deficiency of kidney-yang,the total score of main symptoms,the total score of syndrome and the function of liver and kidney Adverse reactions and the occurrence of new fractures.[Results]After 12 weeks of treatment,the scores of TCM syndrome were lower than those before treatment(P<0.05).There was a significant difference between group A and group B and group C.There was a significant decrease,The t test,P are less than 0.05,the difference between groups there is a statistically significant;A group of effective rate,B group effective rate,C group effective rate,A group of effective than B,C Group,indicating that Cistanche Jianshen Pill with Alun Phosphate treatment is more excellent;patients after treatment in each group of bone mineral density values have been improved,are the emergence of new fractures,P were less than 0.05,A group of bone mineral density Value is higher than B,C two groups,indicating that Cistanche Jianshen pills with alendronate treatment is excellent;patients after 12w treatment,the three groups of osteocalcin than before treatment have increased P less than 0.05,and treatment The difference was statistically significant;after treatment in patients with serum collagen type I coaches end peptide are reduced,P is less than 0.05,A group is superior to B,C group,indicating that Cistanche Jianshen pills with alendronate sodium Reducing the role of serum type I collagen coach peptide is more obvious;before and after treatment of liver and kidney function are abnormal,clinical research is safe.[Conclusion]Alendronate sodium is the third generation of bisphosphonates.It is one of the few drugs approved by our country to be used in the clinical treatment of osteoporosis.Alendronate is suitable for the elderly and the elderly.Postmenopausal women,it has a significant role in increasing bone mineral density,bone mass,repairing bone microstructure,inhibiting osteoclast function,regulating bone metabolism in osteoporotic patients,and its safety in a large number of clinical Application has been affirmed.Cistanche Jianshen pills are derived from Cistanche,Cistanche is a parasitic plant,which has ordered the medicinal value,its function attending kidney yang,Yijing blood,Run intestine,the main kidney yang failure,lack of blood and essence And other symptoms,the main pathogenesis of osteoporosis kidney,spleen,Cistanche Jianshen pills for regulating the endocrine system to promote metabolism and nourish the spleen and kidney has a very significant role,Cistanche on yang and yin deficiency of liver and spleen nucleic acid content And increase the regulation of the role of the adrenal cortex to activate the release of corticosteroids has a very significant role in the effective treatment of spleen deficiency,kidney deficiency so as to achieve the effect of treatment of kidney-yang deficiency of osteoporosis in the elderly.Cistanche Key Kidney Pill with alendronate sodium in the treatment of Kidney-deficiency type of osteoporosis is safe and effective,and Cistanche Jianshen Pill with alendronate sodium alone than the use of sodium alendronate and the general treatment of osteoporosis A group in improving bone mineral density,increased serum calcium,serum collagen I collagen pyridine cross-linked peptide because of B,C group,and safe and effective.