Research On TCM Syndrome Law Of Anxiety And Depression Symptoms Based On Association Rules

Objective:The association rule was used as the main analysis method to study the syndromes of the comorbid anxiety and depression,and cluster analysis was used to assist the results.Through the exploration of comorbid anxiety and depression related symptoms among,and analyze the relevant major syndrome factors,in-depth summary of relationship between syndrome factors,core pathogenesis and syndromes distribution induced comorbid anxiety and depression in traditional Chinese medicine.Methods:A cross-sectional study design was used.During the period of October 2014 to October 2016 of comorbid anxiety and depression in 4 hospitals in Beijing Anding Hospital,Beijing Hui Long Guan Hospital,Beijing University of Chinese Medicine Third Affiliated Hospital,Lianyungang Hospital of Traditional Chinese Medicine,such as data acquisition.The self rating Anxiety Scale(SAS)and the self rating Depression Scale(SDS)were used to screen the suspicious patients.The patients with anxiety and depression were enrolled in the study.The TCM syndrome observation tables were completed and the severity of the patients was recorded by the Hamilton anxiety scale and the depression scale.The data in the observation table is built up through Microsoft Excel 2010.SPSS 21 and data mining software SPSS Modeler14.1 are used to analyze association rules and cluster analysis of data.Under the gui-dance of Chinese medicine theory,studied the regularity of TCM Syndromes of comorbid anxiety and depressionResult:(1)523 patients met the inclusion criteria of comorbid anxiety and depression in patients with a minimum age of 21 years,maximum 65 years old,male to female ratio was 1:1.58.The 40-60 is the high incidence age of this disease,accounting for about 56%.Between 41-50 years of age,the male to female ratio is 1:1.02,indicating that the prevalence of males is significantly higher in this age group.(2)The Hamilton anxiety scale and depression scale were used to study the severity of the disease.The results showed that mild anxiety and depression were the main factors in the study,and the proportion was between 70%-80%.Moderate anxiety depression and severe anxiety and depression was about 10%;in the age between 30-40,moderate and severe anxiety accounted for a higher proportion,reached 25%and 16.7%,severe depression accounted for 22.6%,higher than the average value of the same.In 30-40 years old patients with comorbid anxiety and depression generally heavier;patients with different gender,anxiety and depression are mainly mild,the proportion is about 80%,but the moderate and severe anxiety and depression in male high proportion.Anxiety and depression were more serious in male co morbid patients.(3)Association rules analysis found that the common symptoms of depression and anxiety comorbidity to worry,irritability,nervousness,lassitude,bulimia,difficulty sleeping,dream,interest etc.According to the association rules and the theory of traditional Chinese medicine extract 14 syndrome factors,namely liver qi depression,liver-fire,heart qi deficiency,blood deficiency,heart Yin deficiency,heart yang deficiency,hyperactivity of heart fire,spleen deficiency,spleen deficiency,kidney yin deficiency,kidney yang deficiency,Qi deficiency and phlegm and blood stasis of bile.Using association rules to analyze the relationship of 14 elements of syndrome,and assisted by cluster analysis verification,under the guidance of Chinese medicine theory,summed up the comorbid anxiety and depression of 5 TCM syndromes,respectively:liver depression transforming to fire syndrome,kidney deficiency and liver stagnation syndrome,liver-stagnation and spleen-deficiency syndrome,heart-Cholecyst deficiency syndrome,spleen kidney yang deficiency syndrome.(4)The main symptoms and secondary symptoms of 5 syndromes of anxiety and depression are summarized as follows:The liver depression transforming to fire syndrome,the main symptoms:dry mouth,hypochondriac pain,sleep difficulties,dreaminess,dizziness.Secondary symptoms:facial Hongre,suspicious,headache,tinnitus,wake up early,constipation.The kidney deficiency and liver stagnation syndrome,main symptoms:depression,flank pain,deep sigh,dizziness,fear,backache.Secondary symptoms:foot knees,abdominal distension,chest tightness,shortness of breath,aversion to cold.The liver-stagnation and spleen-deficiency syndrome,The main symptoms:the mental state is not together,flank pain,belching,sigh,diarrhea.Secondary symptoms:aversion to cold,shortness of breath,meiheqi,anorexia,abdominal distension,abdominal pain.The heart-Cholecyst deficiency syndrome,main symptoms:malaise,timidity,fright,palpitation,fear,paranoia,difficulty falling asleep,sad desire to cry.Secondary symptoms:dry mouth,wake up early,shortness of breath,chest pain,sweating,aversion to cold.The spleen kidney yang deficiency syndrome,main symptoms:depression,mental state is not together,fear,dizziness,diarrhea,backache,knee and foot.Secondary symptoms:anorexia,abdominal distension,belching,aversion to cold,hyposexuality.Conclusion:(1)In this study,we use association rules and cluster analysis to explore the distribution of TCM Syndromes of anxiety and depression.Summed up the TCM Syndromes of 5 comorbid anxiety and depression,such as liver depression transforming to fire syndrome,kidney deficiency and liver stagnation syndrome,liver-stagnation and spleen-deficiency syndrome,heart-Cholecyst deficiency syndrome,spleen kidney yang deficiency syndrome.Through the score of syndrome factors,it is found that the factors of the disease are closely related to the heart,liver and gall,and the elements of disease are closely related to fire,Qi deficiency and Qi depression.(2)This study confirms that association rules play a good role in reducing symptoms,reducing order and ascending order of syndromes,and can reflect the characteristics of syndromes of disease accurately,and can be used in the study of TCM syndromes.