Analysis Of Clinical Factors In Liver Metastasis Of Colorectal Cancer

Objective:In China,colorectal carcinoma(colorectal carcinoma,CRC)patients are mostly in an advanced stage,because lack of characteristic symptoms in their early stage.The liver is the first target organ for CRC metastasis,and about 50% of CRC patients have liver metastases.The median survival of untreated patients with liver metastases is only a few months.This study will explore the impact of clinical factors(such as HBs Ag and other clinical factors)on the occurrence of liver metastases in colorectal cancer,and provide new research ideas and directions for the further treatment of liver metastasis of colorectal cancer.Methods: Retrospective analysis of Affiliated Hospital of Qingdao University Medical College in January 2010-June 2011 pathology confirmed 892 cases of colorectal cancer patients.Collect clinical informations about patients,including age,gender,number of positive lymph nodes,surgical approach,tumor location,tumor size,depth of invasion,differentiation degree,histological classification and preoperative laboratory tests include: ALB,bilirubin,LDH and other related serum biochemical test results and AFP,CEA.Follow-up 5 years whether the occurrence of liver metastases,the patients were divided into positive and negative groups according to whether or not they were transferred.Application SPSS19.0 soft version,Single factor analysis using the ?2test,t test and then doing logistic regression analysis.Results: There was no statistically significant difference compared to two groups of gender age,tumor location,size,histological type,whether the stoma,serum albumin,serum bilirubin,ALP,etc.HBs Ag positive liver metastasis rate(13.73%)was significantly lower than HBs Ag negative(24.30%).There were significant differences between the two groups(P <0.01).The differentiation of tumor cells is closely related to the occurrence of liver metastasis,the lower the differentiation,the higher the risk of liver metastasis.The liver metastases of low,medium and high differentiation groups were33.90%,19.40% and 11.11% respectively.There was significant difference between three groups(P <0.01).Liver metastases are also associated with tumor depth of invasion.T4staging(28.94%)was significantly higher than that in T3 stage(20.83%),higher than T2stage(9.52%)was higher than T1 stage(2.43%),there was significant difference(P <0.01)The transfer was positively correlated with the depth of invasion.Compared with patients without regional lymph node metastasis,patients with positive lymph node metastasis were prone to liver metastases and increased with the number of lymph node metastases.The regional liver metastases were 13.19%(N0),28.79%(N1)and 44.64%(N2),and the difference was statistically significant(P <0.05).ALP,LDH,?-GT,CEA,CA199 in the positive group were significantly higher than those in the negative group,while the level of prealbumin was lower than that of the negative group.The difference was statistically significant(P <0.05).Logistic multivariate regression analysis was used to analyze these clinical dates such as HBs Ag,differentiation degree,depth of invasion,lymph node metastasis,PAB,ALP,LDH ?-GT,CEA and CA19-9.The results showed that HBs Ag(+),tumor differentiation,depth of invasion,lymph node metastasis matters,excluding theeffects of PAB,ALP,LDH ?-GT,CEA,and CA199.Conclusion: The liver metastasis of colorectal cancer has nothing to do with gender,age,operation,stoma,tumor location,size,pathological type,serum ALBumin,PAB,serum bilirubin,ALP,LDH,?-GT,CEA,CA199.HBs Ag(+)will reduce the incidence of liver metastases in patients with colorectal cancer.Poorly differentiated tumors,a high degree of tumor invasion,more lymph node metastasis are more likely to have liver metastases.