| Part 1 Epidemiological Characteristics of Mixed Infection in Children with Lower Respiratory Tract Infection Caused by VirusObjective To investigate mixed infection in hospitalized children with lower respiratory tract infection,so as to provide evidence-based basis for clinical treatment and drug selection.Methods Retrospective analysis of the clinical and epidemiological data of 931 children tested positive for respiratory virus hospitalized for treatment of lower respiratory tract infection during June 2015 to May 2017 in Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University.Results 1.There were 931 children with lower respiratory tract infection caused by virus(M 558,F 373)including 669 cases(71.86%)of simple virus infection and 262 cases(28.14%)of mixed infection.Among these cases,mixed mycoplasma pneumoniae infection was found in 157 cases(16.86%),mixed bacterial infection in 94 cases(10.10%),and mixed virus infection in 23 cases(2.47%).2.The mixed infection rates among 463 cases of ~1 age group with 87 cases of mixed infection(18.79%),400 cases of 1~5 age group with 145 cases of mixed infection(36.25%)and 68 cases of 5~ age group with 30 cases of mixed infection(44.12%)had significant difference with each other(?2=41.61,P<0.01).In the ~1 age group,the infection rate of mixed bacterial infection was the highest with 11.88%.And the infection rate of mixed mycoplasma pneumoniae infection in the 1~5 age group and the 5~ age group was the highest,27.25% and 44.12% respectively.3.There were 450 cases of respiratory syncytial virus with 129 cases of mixed infection(28.67%),324 cases of parainfluenza virus with 88 cases of mixed infection(27.16%),127 cases of influenza virus with 41 cases of mixed infection(32.28%)and 51 cases of adenovirus with 25 cases of mixed infection(49.02%).Adenovirus had the highest mixed infection rate,which was significantly different from the other three viruses(?2=9.60,P<0.01).4.There were significant differences in the incidence of mixed virus infection among different seasons(?2=14.49,P<0.05).The highest rate of mixed virus infection was in autumn,followed by winter.There were significant differences in the incidence of mixed bacterial infection among different seasons(?2=13.58,P<0.05).The highest incidence was in winter and there was no significant difference in the incidence of mixed bacterial infection among spring,summer and autumn(?2=0.13,P>0.05).There was no significant difference in the incidence of mixed mycoplasma pneumoniae infection among different seasons(?2=3.75,P>0.05).Conclusions 1.The mixed infection rate of children with lower respiratory tract infection caused by virus was relatively high,and the mixed infection rate of Adenovirus was highest..2.There were significant differences in the detection rate of mixed different pathogens among children of different age groups.In the ~1 age group,the infection rate of mixed bacterial infection was the highest.And in the 1~5 age group and the 5~ age group,the infection rate of mixed mycoplasma pneumoniae infection was the highest.3.There existed seasonal characteristics of the incidence of mixed infections of different pathogens.The season with the highest mixed virus infection rate was autumn,and the season with the highest mixed bacterial infection rate was winter.There was no significant peak of mixed mycoplasma pneumoniae infection rate among different seasons.Part 2 Clinical Characteristics of Mixed Infection in Children with Influenza Virus InfectionObjective To investigate the epidemiological characteristics and the clinical features of mixed infection of hospitalized children with influenza virus infection in Changzhou.Methods Analysis of the clinical and laboratory data of children hospitalized for treatment of acute respiratory tract infection who were tested positive for influenza virus type A and B by direct immunofluorescence during June 2015 to May 2017.Results 1.There were 8226 children hospitalized for acute respiratory tract infection with 140 cases of influenza virus infection(1.70%),of which 78 cases(55.71%)were positive for influenza virus-A and 62 cases(44.29%)were positive for influenza virusB.The median age of the influenza virus-A group was 30.0 months(11.6-53.1)and that of the influenza virus-B group was 51.0 months(26.9-73.1).There was a statistically significant difference in age between the two groups(Z=-3.25,P=0.001).2.The detection rates of influenza virus in spring,summer,autumn and winter were significantly different(?2=75.26,P<0.001).The detection rate in spring was the highest,which was significantly higher than that in winter(?2=3.89,P < 0.05).3.Mixed infection was found in 48 cases(34.29%),mycoplasma pneumoniae infection in 32 cases(22.86%),mixed bacterial infection in 10 cases(7.14%),and mixed virus infection in 8 cases(5.71%).4.There was no statistic difference in age,lower respiratory infection rate,major symptoms and signs between the mixed infection group and the simple infection group.The hospital stay of the mixed infection group was 7.0 days(6.0-8.0),and that of the simple infection group was 6.5 days(6.0-7.0).There was a significant difference in hospital stay between the two groups(Z=-2.11,P<0.05).5.Mixed mycoplasma pneumoniae infection was found in 10 cases(14.93%)in infants and young children group,and in 22 cases(30.14%)in non-infants and young children group.The infection rates of mixed mycoplasma infection in the two groups were statistically different(?2=4.59,P<0.05).Conclusions 1.The detection rate of influenza virus in hospitalized children in Changzhou was the highest in spring,followed by winter.2.The mixed infection rate was relatively high in hospitalized children infected with influenza virus.Mycoplasma pneumoniae was an important pathogen of mixed infection.3.It was difficult to distinguish whether there was mixed infection or not only by clinical symptoms.Mixed infection will prolong the hospital stay;therefore,it is necessary to actively improve relevant pathogenic detections so as to make early diagnoses and perform timely treatment of mixed infection in clinical. |
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