| ObjectiveThis study focused on the analysis of the correlation between TCM syndrome types and leptin in patients with dyslipidemia,correlation between TCM syndrome types and apoAI in the patients with dyslipidemia,correlation between TCM syndrome types and coagulation indicators in patients with abnormal blood lipid by tseting serum leptin,blood lipid indicators and coagulation indicators through clinical observation.This study provided objective basis for early micro dyslipidemia syndrome differentiation and treatment of traditional Chinese medicine.It provided the basis for the early prevention and delay of the progress of AS.At the same time,it explored new ideas for the individualized treatment of dyslipidemia and AS with Chinese medicine.MethodsWe screened 139 patients with dyslipidemia in Dongzhimen Hospital and Aerospace Central Hospital from April 2016 to December 2017.We collected the cases according to the inclusion and exclusion criteria which were made according to the "guiding principles of' clinical research of Chinese medicine new drugs(Trial Implementation)"(2002)and collected the patients' general information,then we filled the TCM syndrome scale and tested blood lipid,blood clotting function and leptin detection,and selected 20 healthy examiners without the history of dyslipidemia.We finally analysed the collected data.Results1 The dyslipidemia patients include 78 male and 61 female cases.Their overall age is 40-74 years old,and the average age is 69.09±8.82 years old.The control group includes 9 male and 11 female cases,and the average age is 59.85±11.58 years old.There is no statistical significant difference in age and sex distribution between the abnormal blood lipid group and the normal control group(P>0.05).The average BMI of the patients with dyslipidemia is 25.58±2.40kg/m~2.The average BMI of the patients in th e normal control group is 23.30±2.70kg/m~2.The difference between the two groups is statistically significant(P<0.05).Among the 139 patients with dyslipidemia,the male case s are more than the cases of the female.Most of the patients are junior middle-school and high-school education cultural level.In terms of living habits,more than half of the patients have a greasy diet,and the frequency of most patients is less than 2 times a week.2 The serum leptin content in patients with dyslipidemia is significantly higher than that in the normal control group(P<0.001).The level of leptin in women with dyslipidemia is higher than that of men(P>0.05).The level of serum leptin in patients with higher BMI is higher(P>0.05).3 The serum apoAI content in patients with dyslipidemia is significantly lower than that in the normal control group(P<0.001).The level of apoAI in women with dysli pidemia is higher than that of men(P<0.01).The level of serum apoAI in patients who se BMI is higer than 24kg/m~2 is significantly lower than that in patients whose BMI is lower than 24kg/m~2(P>0.05).4 In 139 cases of patients with dyslipidemia,the distribution of TCM syndromes r anges from high to low in the order:deficiency of spleen and kidney yang group(28.78%)>phlegm turbidity repression group(23.74%)=qi stagnation and blood stasis group(23.74%)>yin deficiency yang hyperactivity group(12.95%)>deficiency of liver kidney yin group(10.79%).There is no statistical significant difference in sex and age between dif ferent TCM syndrome types(P>0.05).5 The serum leptin content of the patients with dyslipidemia in different TCM syndrome types is different(P<0.05).The serum leptin level from high to low in the order is:phlegm turbidity repression group>qi stagnation and blood stasis group>yin deficiency and yang excess group>deficiency of spleen and kidney yang group>deficiency of liver and kidney yin group>normal control group.According to the further comparison between two,it is concluded that there is a statistically significant difference between normal control group with phlegm turbidity repression group,yin deficiency and yang e xcess group,qi stagnation and blood stasis group,deficiency of spleen and kidney yang group and deficiency of liver and kidney yin group(P<0.05).There is a statistically significant difference between phlegm turbidity repression group with the deficiency of sp leen and kidney yang group,the deficiency of liver and kidney yin group,qi stagnation and blood stasis group and normal control group(P<0.05).6 The serum apoAI content of the patients with dyslipidemia in different TCM syndrome types is different(P<0.05).The serum apoAI level from high to low in the order is:normal control group>phlegm turbidity repression group>yin deficiency and yang excess group>deficiency of liver and kidney yin group>qi stagnation and blood stasis group>deficiency of spleen and kidney yang group.According to the further compariso n between two,it is concluded that there is a statistically significant difference between normal control group and the five TCM syndrome types(P<0.05),and the difference between the phlegm turbidity repression group with the deficiency of spleen and kidney yang group,qi stagnation and blood stasis group,normal control group(P<0.05).7 The serum lipid content of the patients with dyslipidemia in different TCM syndrome types is different(P<0.05).The serum TC level from high to low in the order is:phlegm turbidity repression group>deficiency of liver and kidney yin group>yin deficie ncy and yang excess group>qi stagnation and blood stasis group>deficiency of spleen and kidney yang group>normal control group.According to the further comparison between two,it is concluded that there is a statistically significant difference between normal control group with the phlegm turbidity repression group,the deficiency of spleen and kidney(P<0.05),and the difference between the phlegm turbidity repression group and the deficiency of spleen and kidney yang group,qi stagnation and blood stasis group,yi n deficiency and yang excess group(P<0.05),and the difference between the spleen and kidney yang deficiency group and deficiency of liver and kidney yin group,yin deficiency and yang excess group is also statistically significant(P<0.05).The serum TG level from high to low in the order is:yin deficiency and yang excess group>deficiency of liver and kidney yin group>phlegm turbidity repression group>deficiency of spleen and kidney yang group>qi stagnation and blood stasis group>normal control group.According to the further comparison between two,it is concluded that there is a statistically s ignificant difference between normal control group with phlegm turbidity repression gr oup,deficiency of spleen and kidney yang group,deficiency of liver and kidney yin group,yin deficiency and yang excess group(P<0.05).And the difference between qi stagnat ion and blood stasis group and yin deficiency and yang excess group is also statistically significant(P<0.05).The serum HDL-C level from high to low in the order is:normal control group>phlegm turbidity repression group>qi stagnation and blood stasis group>deficiency of spleen and kidney yang group>yin deficiency and yang excess group>deficiency of liver and kidney yin group.According to the further comparison between two,it is concluded that there is a statistically significant difference between normal control group and five TCM syndrome types(P<0.05).The serum LDL-C level from high to low in the order is:phlegm turbidity repression group>deficiency of liver and kidney yin group>yin deficiency and yang excess group>qi stagnation and blood stasis grou p>deficiency of spleen and kidney yang group>normal control group.According to the further comparison between two,it is concluded that there is a statistically significant dif ference between normal control group with phlegm turbidity repression group,deficiency of liver and kidney yin group,yin deficiency and yang excess group(P<0.05).And the difference between the phlegm turbidity repression group and the deficiency of spleen and kidney yang group,qi stagnation and blood stasis group,yin deficiency and yang excess group is also statistically significant(P<0.05).And the difference between the spleen and kidney yang deficiency group and deficiency of liver and kidney yin group,yin deficiency and yang excess group is also statistically significant(P<0.05).The serum apoB level from high to low in the order is:phlegm turbidity repression group>yin deficiency and yang excess group>deficiency of liver and kidney yin group>qi stagnation and blood stasis group>deficiency of spleen and kidney yang group>normal control g roup.According to the further comparison between two,it is concluded that there is a sta tistically significant difference between normal control group with phlegm turbidity repression group,deficiency of liver and kidney yin group,qi stagnation and blood stasis group,yin deficiency and yang excess group(P<0.05).And the difference between the phlegm turbidity repression group and the deficiency of spleen and kidney yang group,qi stagnation and blood stasis group is also statistically significant(P<0.05).8 The coagulation indicators of the patients with dyslipidemia in different TCM syndrome types are different(P<0.05).The PT level from high to low in the order is:deficiency of spleen and kidney yang group>phlegm turbidity repression group>deficiency of liver and kidney yin group>normal control group>yin deficiency and yang excess group>qi stagnation and blood stasis group.According to the further comparison between two,it is concluded that there is a statistically significant difference between the sple en and kidney yang deficiency group and phlegm turbidity repression group,deficiency of liver and kidney yin group,yin deficiency and yang excess group,qi stagnation and blood stasis group(P<0.05).Comparing the Internetional normalized ration(INR)level between different groups,the level of INR in spleen kidney yang deficiency group is th e highest,followed by yin deficiency and yang excess group,phlegm turbidity repression group and normal control group,and the lowest level of INR is in liver kidney yin deficiency group and qi stagnation blood stasis group.According to the further comparison between two,it is concluded that there is a statistically significant difference between the spleen and kidney yang deficiency group and phlegm turbidity repression group,deficiency of liver and kidney yin group,qi stagnation and blood stasis group,normal control group(P<0.05).FIB,APTT and TT level in different TCM syndrome types have no statistically significance(P>0.05).9 Serum leptin levels in patients with dyslipidemia are positively correlated with serum lipid index TC,apoB and LDL-C(P<0.05).With the increase of serum leptin,the TC,apoB and LDL-C in patients with dyslipidemia are also increased(P<0.05).10 TCM syndrome score is correlated with related indexes.The turbid phlegm group syndrome scores are positively correlated with leptin,apoB,TC and LDL-C level(P<0.05).The syndrome scores of spleen and kidney yang deficiency group are negatively related to apoAI,TC,HDL-C and APTT(P<0.05).The syndrome scores of blood stasis syndrome group are negatively correlated with PT and INR(P<0.05).The syndrome scores of yin deficiency and yang excess group are positively correlated with leptin and neg atively related to TC and LDL-C(P<0.05).Conclusion1 The phlegm turbidity repression syndrome,spleen and kidney yang deficiency syndrome and qi stagnation and blood stasis syndrome are the main syndrome types of dyslipidemia patients,the syndrome of yin deficiency and yang hyperactivity is less,and the deficiency of liver and kidney yin deficiency syndrome is the least.2 The level of leptin of the phlegm turbidity repression syndrome and qi stagnation and blood stasis syndrome is relatively high.The level of leptin in spleen and kidney yang deficiency is the lowest.Leptin level can be used as an objective indicator of TCM syndrome differentiation in dyslipidemia patients.3 The level of apoAI of the phlegm turbidity repression syndrome is relatively high.The level of apoAI in spleen and kidney yang deficiency is the lowest.ApoAI level can be used as an objective indicator of TCM syndrome differentiation in dyslipidemia patients.4 Blood lipid indexes can reflect different syndromes.The level of serum TC,TG and apoB in patients with dyslipidemia is closely related to the the phlegm turbidity repression syndrome.The decrease of them is closely related to the spleen and kidney yang deficiency syndrome.5 The level of PT and INR in patients with dyslipidemia is related to spleen and kidney yang deficiency syndrome,and the decrease of PT and INR level is closely related to qi stagnation and blood stasis syndrome.They can be considered as one of the basis of syndrome differentiation.6 There is a correlation between leptin,blood lipid indexes and coagulation indicators with TCM syndrome scores.They can reflect the difference and degree of TCM syndrome. |
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