The Study And Application On Molecular Imprinting Polymers Modified Electrodes

Molecular Imprinting Polymers (MIPs) is a specificity of certain moleculesrecognition ability of polymer materials, because it has the structure-activityreservation, specific selectivity, simple implementation, and many other advantages.It has a wide range of application in chromatogram separation, solid phase extraction,bionic food, membrane separation, sensor, capillary electrochromatography, as wellas clinical medicine and other fields. In this paper, combining the molecularimprinting technology (MIT) and electrochemical detection (ECD), I have preparedfour kinds of molecularly imprinted membrane electrochemical sensor based onglassy carbon electrode. The content is described as five chapters:1. This paper introduces the preparation of ethylparaben electrochemical sensorbased on o-phenylenediamine and analytical method of ethylparaben. The experimentuses o-phenylenediamine as functional monomer and kaempferol as templatemolecule, prepares molecularly imprinted membrane of ethylparaben throughelectrochemical polymerization. And cyclic voltammograms is used to indirectlyestablish analytical method of ethylparaben base on the medium of K3[Fe(CN)6].Experimental result shows that this sensor has high sensitivity and grate selectivity.The sensor provided a linear range from2.5×10-6?1.0×10-5mol/L and a detectionlimit of8.61×10-8mol/L. The sensor is used to analysis ethylparaben in lomefloxacinhydrochloride eyedrops, the result has a high accuracy rate.2. The experiment uses o-phenylenediamine as functional monomer andkaempferol as template molecule, preparing molecularly imprinted membrane ofethylparaben through electrochemical polymerization. Experimental result shows thatthis sensor has high sensitivity and grate selectivity. The sensor provided a linearrange from2.5×10-6?1.0×10-5mol/L and a detection limit of8.61×10-8mol/L.3. A novel molecular imprinting polymer electrochemical sensor has beenfabricated. The experiment uses ferulic acid as template molecule, MMA as functionalmonomer, AIBN as an initiating agent and EGDMA as cross-linking agent. Thiselectrochemical sensor has high sensitivity and great selectivity. The sensor provideda linear range from4.0×10-6?2.0×10-5mol/L(R2=0.9924) and a detection limit of1.69×10-7mol/L.4. A novel molecular imprinting polymer electrochemical sensor has beenfabricated. This experiment uses magnolol as template molecule, MMA as functionalmonomer, AIBN as an initiating agent and EGDMA as cross-linking agent. Thiselectrochemical sensor has high sensitivity and great selectivity. The sensor provideda linear range from2.5×10-6?5.0×10-5mol/L(R2=0.9937) and a detection limit of8.3×10-7mol/L.