Study On The Reaction Of Aromatization And Functionalization Based On The Aryl Propanol Oxidation

Pyrrole compounds are the very important members in heterocyclic compounds,they have wide biological and pharmacological activity,and they are also the focus in the medicine field.This paper reports a method to prepare N-substituted pyrroles and N-substituted indoles through decarboxylative aromatization.The synthesis method is that under the oxidant,N-substituted benzyl-(E)-4-benzoyloxy-L-proline reacts with substituted phenylpropanols to afford the N-substituted pyrroles.Using the same method,indoline-2-carboxylic acid reacts with substituted phenylpropanols to afford N-substituted indoles.The total target compounds are 20,and all the target compounds were characterized by 1H NMR,13C NMR and HRMS.Indole compounds are widely distributed in the nature,in the medicine field,they are becoming the focus in the development of novel drugs for scientists.This paper reports a new method to prepare.functional aryl acrylic aldehydes.The synthesis method is that under the oxidant and catalyst,substituted phenylpropanols reacts with,substituted indoles to afford the final products.The total target compounds are 20,and all the target compounds were characterized by 1H NMR,13C NMR,and HRMS.