Development On Application Of Phenazine Derivatives In Supramolecular Chemistry

A wide variety of phenazine compounds are no stranger to organic chemistry researchers,it widely exists in organic natural products together with good biological activity.The synthetic process is simple and the functionalization of molecular structure is comparatively easy of phenazine compounds with natural skeleton.These compounds with multiple sites and large conjugated system,which make it easy to form hydrogen bond,ionic bond and?-?interaction and so on.Therefore,the phenazine compounds have extensive application in supramolecular chemistry.Molecular recognition?MR?and supramolecular self-assembly?MS-A?is has been two important research direction of supramolecular chemistry,this review article highlights advances in the research of the development on application of phenazine derivatives in MR and MS-A in recent years.Part 1:In this part of the work,we designed and synthesized a new phenazine derivatives?L-1?which functionalized by imidazole and furan,the compound can ultraviolet and fluorescence dual channel detect silver ions among other coexist metal ions in aqueous solution.The detection limit is 3.25×10^-7 M.In addition,the sensor can be recognized as a recyclable material.It is important to note that,the test kits and silica gel plates based on L–1 was prepared which can canconvenient and quick detection of silver ions in aqueous medium.Part 2:In this part of the work,we have designed a kind of sensor?T?which can continuously detect of CN^-and HSO₄^-in aqueous system.Phenazine group as the signal report group,imidazole and hydroxyl hydrogen protons as the recognition site in the sensor.The detection limits of T to CN^-and T+CN^-to HSO₄^-were to be 0.089?M and 0.00146?M,respectively.In addition,the probable mechanism proved by the¹H NMR,MS and IR spectrum,which shown that the recognition of CN^-through deprotonation and HSO₄^-by formation of multiple hydrogen bonds among HSO₄^-,HCN and T.As a result,we put forward an efficient,convenient and quick recognition idea for anionic.Part 3:In this part of the work,we design a turn-on fluorescent sensor?H-1?which can detect CN^-ion in water.In the sensor H-1,the phenazine as the signal report group and hydroxyl group as recognition site.The ¹HNMR,IR and MS spectrum prove the probable recognition mechanism.The detection limit of the sensor towards CN^-is 5.65×10^-7 M,other competitive anions had nearly no influence on the recognition behavior.In addition,test strips based on H-1 were fabricated,which can convenient and efficient detection of CN^-in aqueous solution.Notably,we use the sensor to detect the existence of CN^-in food samples.Part 4::In this part of the work,we designed a phenazine derivatives of metal complexes based sensor(L2-Zn²⁺).The sensor can colorimetric and fluorescent selective recognition of CN^-without other anionic interference,the sensor based on metal complexes for CN^-is relatively rare.In the open hole,the sensor to the CN^-ion also achieved the very good recognition effect.In addition,the test paper based on sensor L2-Zn²⁺conveniently can be used to detect the CN^-in aqueous solution.