Homotypic-cell Membrane Cloaked Nanocarrier Platform To Increase The Targeting Ability And Immunocompatibility For Cancer Therapy

Development of high efficient drug delivery system is high demanding but still a challenging task for cancer chemotherapy.The drug delivery systems usually suffer from insufficient targeting ability toward tumor lesions,and being easily recognized and cleared by the immune system.In order to enhance the therapeutic effect of chemotherapy,increase the toxicity of drugs to tumor tissues,herein,we develop a novel drug nanocarrier by utilizing the homotypic aggregation of the cancer cell via biomimetic strategy.The work of this paper includes the following two aspects:1,In this paper,we develop a novel drug nanocarrier(Hep M-PLGA)by utilizing the homotypic aggregation of the cancer cell via biomimetic strategy.Structurally,Hep G2 cell membrane is used as the cloak of Hep M-PLGA and PLGA nanoparticle is used as the core.Hep M-PLGA exhibits satisfied stability,immunocompatibility and especially excellent homotypic targeting ability toward Hep G2 cells.At the aid of Hep M-PLGA,Doxorubicin(Dox)can be carried directly to the tumor lesion and tumor growth is dramatically inhibited,while the damage on the major organs is ignorable.These results together vote the biomimetic Hep M-PLGA as a promising drug delivery system for cancer chemotherapy.2?In this paper,we develop a novel drug nanocarrier(Hep M-TSL)by utilizing the homotypic aggregation of the cancer cell via biomimetic strategy.Structurally,Hep G2 cell membrane is used as the cloak of Hep M-TSL and TSL nanoparticle is used as the core,chemotherapeutic drugs Doxorubicin(Dox)and photothermal conversion agent(ICG)are encapsulated.Hep M-TSL exhibits satisfied stability,immunocompatibility and especially excellent homotypic targeting ability toward Hep G2 cells.At the aid of Hep M-PLGA,under the irradiation of near-infrared laser,ICG causes high temperature,thermosensitive liposomes“open” and make drug doxorubicin(Dox)release.In this way,Dox can be carried directly tothe tumor lesion,and tumor growth is significantly inhibited,synergistic treatment of photothermal therapy and chemotherapy is realized.These results indicate that the biomimetic Hep M-TSL is a promising drug delivery system for cancer therapy.