NH₄OAc Promoted Solvent-free Synthesis Of Indoles Based On Cyanoacetylindole

For many years,nitrogen-containing heteroaromatic compounds have attracted wide attention because of their remarkable biological activity.As an important part of it,indoles also have extensive biological characteristics.The synthesis of indole compounds and their derivatives has also become one of the hot topics of scholars.In this paper,3-cyanoacetylindoles were used as the substrate to study the synthesis of indole derivatives under solvent free conditions.In the first part,3-cyanoacetylindoles were prepared and used as the reaction substrate to investigate the simple,efficient synthesis of cyano-chalcones derivatives containing fluorene structure under the solvent-free conditions.In the second part,the reaction properties of 3-cyanoacetylindoles with salicylaldehydes under the promotion of solvent free and ammonium acetate were discussed,and an effective method for the synthesis of 3-?indole-3-yl?-chromenone compounds was constructed.In the third part,the reaction properties of 3-cyanideacetylindoles with o-nitrobenzaldehydes was investigated and studied in NH₄OAc-SnCl₂·2H₂O system.The effective synthesis method of one pot synthesis of 2-?indol-3-yl?-quinoline-3-carbonitrile derivatives was successfully constructed.