Pd-Catalyzed Asymmetric Aryl C-P Coupling Reaction

As one of the basic properties of nature,chirality has attracted more and more attention in the fields of biology,medicine and chemistry.In addition to carbon atoms,the atoms of nitrogen,phosphorous and sulfur can also be used as chiral centers.Chiral ligands containing phosphorus are widely used in asymmetric catalyzed by transition metals.Chiral phosphine ligands have important effects on the reactivity and enantioselectivity of asymmetric reactions.The design and synthesis of new chiral phosphine ligands are pretty challenging.With the help of our research group's experience in asymmetric carbon heteroatom bond coupling through asymmetric synthesis methods can effective on carbon bond between aryl phosphine for construction,implementation of the intermolecular coupling reaction of carbon phosphine,thus obtained phosphine ligands can be used in the asymmetric catalytic reaction.Through continuous exploration of reaction conditions,we have successfully explored the way of asymmetric synthesis of three aryl phosphine oxide by means of kinetic resolution strategy and transition metal palladium catalyst.The compounds can be used directly or after simple reduction as chiral phosphine ligands to a variety of asymmetric synthesis reactions.This method has a mild reaction condition,a wide range of substrates,and an ideal yield and enantioselectivity in the reaction.After simple recrystallization,the product can reach 99% ee,which greatly improves its practical application value.