Synthesis Of Acrylate Block Copolymer And Its Immobilization To Hemoglobin

Faced with the rapid development of today,people have been closely linked with polymer materials,and put forward higher requirements for polymer materials,starting from the design of polymer chain structure so that the macroscopic properties of the material are more excellent,and the use is more extensive.This is particularly important,and controlled/"active"free radical polymerization is one of the important means to achieve this goal.In this paper,1,1-diphenylethylene(DPE)was used as a radical polymerization chain transfer agent,azobisisobutyronitrile(AIBN)as an initiator,butyl acrylate as the first monomer,and the precursor of n-butyl polyacrylate was synthesized.Butyl ester precursor,and the second monomer glycidyl methacrylate is added to the polymer precursor,and heating is initiated to synthesize n-butyl polyacrylate-b-polyglycidyl methacrylate(PnBA-b-PGMA)Block copolymers.The molecular weights and molecular weight distributions of polymer precursors and block copolymers were characterized by gel permeation chromatography(GPC)using 1H NMR and FTIR block copolymers.The structure was characterized and differential scanning calorimetry(DSC)was used to measure the glass transition temperature of the block copolymer.In addition,in this paper,DPE was used as a chain transfer agent,Azobisisobutyronitrile(AIBN)as an initiator,glycidyl methacrylate as the first monomer,and styrene as the second monomer.Poly(glycidyl acrylate)-b-polystyrene block copolymers,explored the control of DPE in the polymerization reaction and its effect on polymer molecular weight and molecular weight distribution,using GPC on the polymer The molecular weight and molecular weight distribution of the precursor and block copolymer were characterized.The chemical structure of the polymer was characterized by ~1H NMR and FTIR,and the glass transition temperature of the precursor polymer and block copolymer was investigated by DSC.Finally,poly(glycidyl methacrylate)-b-polystyrene block copolymer nanofibers were prepared by liquid shear method.The ratio and dosage of precipitant and viscous medium in liquid shearing system were studied in detail.Effect of velocity on the morphology of block copolymer fibers.In addition,the effects of block copolymer fibers with different composition ratios on the immobilization efficiency of bovine hemoglobin were explored.