Studies On Synthesis Of Contains Fluorine, Sulfur, Phosphorus And Other Heteroatomic Compounds With High-efficiency Through The Free Radical Reaction

The free radical reaction is one of the types of the basic reaction in organic synthesis.In recent years,due to the rich and efficient nature of copper promoted free radical reaction,it is widely concerned.More and more copper promoting free radical reactions have been developed.This paper focuses on the research of free radical reaction under copper catalysis and related sulfonylation,trifluoromethylation,dehydrogenation and ifunctionalization.This thesis is composed of four parts:1?In this paper,the research progress of C-CF₃ and C-SO₂ bond in the last decade is reviewed.The classification is described by different trifluoromethy-lation reagents and different sulfonylation reagents.2?Synthesis of trifluoromethylated quinolone-2,4?1H,3H?-diones compounds were prepared by using the o-cyanoarylacrylamides with sodium trifluoromethylate in the control of Cu?ClO₄?₂·6H₂O.Through a similar process,sodium sulfonate was used as sulfonylating agents to obtain the sulfonylated quinolone-2,4?1H,3H?-diones.3?Study on the catalytic oxidation dehydrogenative coupling of aromatic carboxylic acid and phosphatide in copper catalysis.Through the cheap and accessible aromatic carboxylic acid and phosphatate as the raw material,it was realized with high efficiency to synthesis acyl phosphate under the catalysis of Cu₂O,4?Study on the copper-catalyzed decarboxylative disulfonylation of alkynyl carboxylic acids.Using aryl propionic acid and sulfonic acid as the raw material,a decarboxylation bisulfonation reaction is carried out under the catalyzed of Cu?ClO₄?₂·6H₂O,so that?E?-1,2-disulfonylene compound was constructed with high efficiency and high stereoselectivity.