The Self-assembly System Of Amino Acids And Short Peptides Modified By Fmoc:Structural Regulation And Application Of Biological Medicine

Self-assembly,widely existing in nature at all scales,plays crucial roles in preparation of functional architectures and in elucidating the complex life evolution process.Self-assembly of biological molecules provides a new strategy for building functional materials.Intermolecular mechanisms provide a new method for constructing functional assemblies.We choosed Fmoc-amino acids and Fmoc-oligopeptides to construct functional biomolecular assembly through simple regulation and provided a safer and more effective way for biological imaging and therapy.We achieve by ultrasonic irradiation the direct solid-solid transition of bioinspired dipeptide organization from triclinic structured aggregates to nanofibers and eventually to monoclinic nanobelts with strong polarized luminescence.Such a sonication-modulated solid-solid phase transition evolution is governed by distinct molecular interactions at different stages of structural organization.The resulting crystalline nanobelts are for the first time applied for polarization imaging of cells,which can be advantageous to directly inspect the uptake and fate of nanoscale delivery platforms without labeling of fluorescent dyes.We report here a simple but versatile strategy for formation of broad-spectrum antibacterial metallohydrogels by coordinated self-assembly and local mineralization for localized delivery and sustained release of antimicrobial amino acids and silver nanoparticles(AgNPs),with the reduced drug dosage and toxicity yet improved bioavailability and prolonged drug effect.Such coordinated hydrogels exhibit significant antibacterial efficiency against both Gram-negative(E.coli)and Gram-positive(S.aureus)bacteria in cells and mice resulting from the synergy between the amphiphilic nature of Fmoc modified amino acids and broad-spectrum antibacterial activity of AgNPs,without pathologic lesion for primary organs,merely through wound dressing of the amino acid coordinated hydrogels.Functional systems are fabricated via hierarchical self-assembly of small biomolecules,which can be applied in assembly dynamics and biological imaging and therapy.The key point to assembly-induced functional enhancement is to design molecular structure of building blocks based on the synergy of weak intermolecular interactions.