Preparation And Characterization Molecularly Imprinted Polymers With Doping Of Carbon Nanotubes

Molecular imprinting technology is a technology that has emerged in recent years to artificially synthesize polymers with specific recognition sites.The molecularly imprinted polymers(MIPs)have special recognition abilities.Like antigens for antibodies,enzymes for substrates,molecularly imprinted polymers have specific recognition properties for imprinted molecules.Compared with biological entities,molecularly imprinted polymers have attracted the attention of scientists because of its advantages of high affinity,high selectivity,strong resistance to harsh environments,good stability,and long service life.It's can improve its characteristics effectively that preparing the composite materials.Carbon nanotubes are a kind of material with special structure.Both ends of the carbon nanotubes are basically sealed.It has a large aspect ratio and possesses many unique properties.The surface of carbon nanotubes usually has some unsaturated bonds,and the surface area is relatively large,and its properties can be used as energy storage materials.Carbon nanotubes have high modulus and high strength,and they are made into composite materials with their engineering materials as a matrix,with good strength,elasticity,fatigue resistance and isotropy.Carbon nanotubes are widely used in the preparation of composite materials.The carbon nanotubes are added to the preparation process of the molecularly imprinted polymer.Because the carbon nanotubes have a large specific surface area,the exposure of the imprinted polymer recognition site facilitates the elution of the template during the preparation and increases the number of imprinting sites.Carbon nanotubes have large cavities,which increase the number of recognition sites more evenly distributed,increase the effective adsorption area,enhance the recognition ability of template molecules,and increase the imprinting efficiency.The carbon nanotube-doped molecularly imprinted polymer can be applied to a drug delivery system due to its chemically safe and harmless nature,and can be used as a novel slow-release composite material.It's a hot topic that adding the Carbon nanotubes in to the preparation of MIPs,the properties of Carbon nanotubes and MIPs are combined perfectly.The CNT/MIPs can be used as cattier of template,because of thehydrogen-bonding between template and materials.This kind of compound material with slow control function acts as a drug carrier,and changes the drug drug release system through a release process.This material enables the drug to be targeted to the lesion and release the drug slowly or at a zero level within a certain period of time so that the drug has Smooth plasma concentration.The molecularly imprinted polymer is used as a drug carrier,and drug release can be controlled by a diffusion process.This novel drug release system causes the binding force of the two to increase due to the hydrogen bonding between the polymer and the template molecule.The rate of drug release thus makes it possible to provide molecularly imprinted polymers as drug carriers.In this work,carbon nanotubes were introduced into the synthesis of MIPs,the Capecitabine(CAP)molecularly imprinted polymers was incorporated with multi-walled Carbon nanotubes(MWCNTs)were developed.With CAP as template,the methacrylic acid(MAA)and 9-Vinylanthracene can be used as functional monomer,besides ethylene glycol dimethacrylate(EDMA)is crosslinkers,trichloromethane was used as solvent.The imprinting efficiency of MIPs was evaluated by adsorption experiment,furthermore,the control released performance of MIPs was investigated by drug release.The results show that the CNT/MIPs can be used as cattier of CAP,it can control template release approximately 4 hours,compared with CNT/NIPs is 1.3 hours.In the follow work,the influence of the new inorganic nanometer material POSS,The results show that replacing the carbon nanotubes in the synthetic system with inorganic nanomaterials POSS,in this preparation system,POSS can not effectively improve the selectivity of POSS/MIPs.The PS/MIPs and PMMA/MIPs prepared under macromolecular crowding conditions cannot effectively increase the selectivity of the molecularly imprinted polymer,which may be due to macromolecular crowding agents that can only increase the selection performance of specific imprinted materials.