The Preparation And Properties Of Anti-bacterial Silicone Rubber

Silicone rubber has been widely used in the biomedical field due to its low toxicity,physiological inertness,excellent gas permeability and good biocompatibility.However,the extremely high surface hydrophobicity resulting in significant adsorption of bacteria restrains the further use of silicone rubber.Thus,modification of the surface properties is necessary for the bioapplication of silicone products.In this work,anti-fouling and antibacterial silicone film surface were made,respectively.(1)Sulfobetaine zwitterionic compounds were covalently grafted onto the surface of a silicone film by ultraviolet(UV)curing after the surface was pretreated by high-energy vacuum ultraviolet(VUV)irradiation.A cross-linked and a comb-like zwitterions layer were obtained,respectively,in the presence and absence of cross-linking agent,respectively.Comparative studies were carried out to investigate the effects of the structure of the modified surface on the hydrophilic stability and antifouling activity.The results showed that VUV-UV irradiation is an efficient modification method to introduce hydrophilic groups onto the silicone film surface.(2)The covalently linked zwitterions endowed the silicone surface with good hydrophilicity and hydrophilic stability.The modified surfaces showed a reduction in the adhesion of bacteria and an improved biocompatibility relative to the pristine silicone surface.The cross-linked layer exhibited more complete coverage of the surface and better hydrophilic stability,antifouling activity and biocompatibility than the comb-like layer.(3)Polydopamine coated silicone film was obtained after pre-treated by VUV irradiation.The catechol and amino of polydopamine could bind and reduce silver irons,thus it is facile to deposit nanosilver particles on silicone film surface.The activated-SF-PDA-Ag fabricated by the above method exhibited excellent antibacterial properties against E.coli,S.aureus and P.aeruginosa.In vitro cell assay suggested that the activated-SF-PDA-Ag has good biocompatibility.