Gold Nanopariticles Graphene Modified Glassy Carbon For Electrochemical Determination Of Erythrosine

Molecular imprinting electrochemical sensor(E-MIPs)is a kind of detection device that combines molecular imprinting technique with electrochemical sensors.That molecular imprinted polymers(MIPs)as the identification element of the E-MIPs have specific binding with the target materials causes current response changing.The electrochemical signal is related to the concentration of the measured objects.This paper reports a novel molecularly imprinted sensor that can directly and fast detect erythrosine in practical samples whithout any sample pretreatment.In this account,sodium citrate was used as a reductant and stabilizer to decorate reduced graphene oxide(rGO)with 2-aminoethanethiol(2-AET)functionalized and well-distributed gold nanoparticles(AuNPs),as well as improve the sensitivity and stability of rGO deposited on the electrode surface.The molecular imprinted polymer(MIP)was prepared on the electrode surface via cyclic voltammetry with erythrosine(ERT)as the template molecule,and m-dihydroxybenzene(m-DB)with o-phenylenediamine(o-PD)as the functional monomer.After eluting the template from the polymer by 0.5mol/LNaOH,the molecularly imprinted polymer can adsorb and recognize erythrosine.K3Fe[(CN)6]was used as electrochemical probes and erythrosine was detect indirectly make use of "door effect".Using differential pulse stripping voltammetry(DPV)and its peak current difference can measure,analyze and optimize the parameters that affect the performance of the sensor.CV and EIS were used to characterize the molecularly imprinted membrane.What's more,SEM was used to characterize the surface morphology of the modified electrode.In the context of the optimal experimental parameters,the concentration of EC solution was calibrated by the technology of DPV and study on the performance of molecularly imprinted sensor(MIP/AuNPs/2-AET/rGO).In addition,the specificity,the practical ability and the stability of the manufactured imprinted sensor were evaluated.The results revealed that the sensor could achieve a wide linear range(3.75×10-8 to 1.50×10-4 M)and a low detection limitation(4.77×10-9 M),meeting the requirements of ERT trace analysis.The stability and reproducibility of the prepared molecular imprinted electrodes showed excellent long-term stability and relevant reproducibility,making these platformspromising electrochemical sensors for future determination.