Preparation And Characterization Of Metal-Organic Frameworks Based On Nitrogen-Containing Ligand

Metal-organic framework(MOFs),which were designed by connecting various metal ions or metal clusters(as nodes)and organic linkers(as linker)through coordination bonds,are a class of porous materials with specific high porosity and crystallinity.The structures of MOFs are diverse and controllable,since regulation of metal species or the types of organic ligands could obtain diverse structures.Recently,stable MOFs are invoking intensive attention,one of the factors that affect the stabilities of MOFs is the ligands,suitable ligands can be selected to design and synthesize stable MOFs.In this paper,to synthesize MOFs with high stability in alkaline solution,a linear ligand1,4-benzenedi(4'-pyrazolyl),in which the pyrazolate group was considered as a soft Lewis base,was used to react with two relatively soft Lewis acid Ni(II)and Zn(II)metal ions,to constructed stable MOFs structure.For the obtained materials PFC-6 and PFC-7,their structures,thermal stabilities,acid-base stabilities and the DCF drug uptake/release behaviors were investigated.The main research content and results are as follows:1.PFC-6 was synthesized by solvothermal method.Structure,acid-base stability,thermal stability and the DCF drug uptake/release behavior of the material were investigated.The results showed that PFC-6 exhibits excellent stability from pH=2 to pH=14,and reaches the maximum loading capacity of 89.4 mg/g.Meanwhile,74.9 % DCF were released.All results proved that PFC-6 is a promising drug carrier with high stability,high loading capacity,and slow release rate.2.PFC-7 was synthesized by solvothermal method.Structure,acid-base stability,thermal stability analyzed.The DCF drug uptake/release behavior of the material were investigated.The results showed that PFC-7 exhibits excellent stability from pH=2 topH=13,and reaches the maximum loading capacity of 209.8 mg/g.Meanwhile,89.4 %DCF were released.All results proved that PFC-7 is a promising drug carrier with high stability,high loading capacity,and slow release rate.