Technique Of Preparation And Quality Control Study Of Maxing Cough Granule

Maxing cough granule is famous for the old Chinese medicine and used for long time in clinical experience by ephedra,bitter almond,loquat,licorice,one hundred,gypsum,etc.,with clear heat,cough and asthma effect,for phlegm Meaning,lung failure and chronic cough than those who declared.In this paper,basis on the Maxing particles extracted process,conducted research for the Maxing particles extract powder to pre-formulation studies,the pharmaceutical technology,and the preliminary assessment of the quality of granule,laying the foundation of the further research.Specific studies are as follows:Pre-formulation study:The effects of Maxing extract powder micromeritics major parameters such as bulk density,angle of repose,dissolve resistance,pH,moisture absorption,critical relative humidity.through the children Maxing extract powder melting,bulk density,angle of repose,the determination of the critical relative humidity and hygroscopic known water-soluble extract powder Maxing children better,but less liquid and has a strong hygroscopic.in order to Maxing granular dosage form design,The study on the preparation technology:Use granulation forming,hygroscopocity,dissolubility "normalized value" as an index,proposed merger optimize binomial equation of response surface method is used to analysis the results,and verified this optimized formulations(deviation under 5%),Verify model predictions has a good fit.The extract powder-(sugar+dextrin)ratio of 1:2,volume fraction of 80%ethanol as a wetting agent made of soft material,extract powder:80%ethanol ratio of 30:1.The preliminary study on the quality evaluation:Reference to the 2015 edition of Chinese Pharmacopoeia,check on the granule,such as the Traits,inspection,TLC,To establish a method for Ephedrine,determine the content of amygdalin.Include chromatographic conditions:mobile phase selection,the maximum absorption wavelength selection,flow rate,column temperature choice.The results showed that the method is accurate and reliable,can be used to study Maxing granule quality standards.