The Morphological Control And Application Of Phenylphosphonates Material

The control of metal phosphonate material with special morphology has become a research hot spot.Here,the control and synthesis nickel phenylphosphonate with special morphology were conducted,and two nickel phenylphosphonate material with different morphologies,flower-like microsphere and monolith were obtained.Also,the aluminum phenylphosphonate microspheres were used as carriers to load biomolecule and drug.The flower-like nickel phenylphosphonate microspheres were prepared using phenylphosphonic acid and nickel chloride in the presence of urea at hydrothermal conditions of 100?.The urea hydrolyzed under hydrothermal conditions gradually increased the pH value of the synthesis system.The morphology composition and structure of the product was characterized by SEM,FT-IR,XPS,XRD and TG-DTA.Flower-like nickel phenylphosphonates were self-assembled by many petals with micrometer scale around the center of sphere to form microspheres.Furthermore,inorganic nickel phosphate with the same morphology can be obtained by calcination of flower-like nickel phenylphosphonate microspheres at high-temperature.The nickel phenylphosphonate nanoparticles with irregular shape was also prepared by using phenylphosphonic acid and nickel chloride at the different reaction conditions(synthesis temperature and the initial concentration of the reactants).The nickel phenylphosphonate monolith with hierarchical pore structure was self-assembled by the nanoparticles during post-treatment process.The morphology,composition and pore structure of nickel phenylphosphonate monolith characterized by SEM,FT-IR and N2 sorption.The nickel phenylphosphonate monolith presents hierarchical pore,including micropore,mesopore and macropore.The shape of nickel phenylphosphonate monolith can be controlled by using molds with different shapes obtaining desired block shape to meet the requirement of practical applications.In addition,the aluminum phenylphosphonate microspheres(ys/hs-AlPhPO)were used as carriers for biological molecule and drug.The adsorption behavior of ys-AlPhPO and hs-AlPhPO for salmon sperm DNA can be attributed to Langmuir model of monolayer adsorption and Freundlich model of multilayer adsorption.The kinetics adsorption of ys-AlPhPO and hs-AlPhPO for salmon sperm DNA fits pseudo-second order kinetic model.The ys-AlPhPO and hs-AlPhPO was used as drug carrier for loading anticancer drug of doxorubicin hydrochloride and folic acid of targeting agent to establish drug delivery system targeting cancer cells.Two aluminum phenylphosphonate microspheres can efficiently load anticancer drug of doxorubicin hydrochloride,and load enough folic acid to meet the requirement of targeting to cancer cells.The successful synthesis of two nickel phenylphosphonate with different morphology enriches the composition of the family of transition metal phosphonates,and the method is also generally practicable for morphological control of transition metal phosphonate.The aluminum phenylphosphonate microspheres as carriers for loading biological molecules and drugs can provide a paradigm for the application of metal phosphonate in the field of biology and medine.