Studys On The Preparation And Quality Standards Of Huangqi Guizhi Wuwu Decoction Granules

HuangqiGuizhi wuwu Decoction granules prescription granules prescription is the classic clinical prescription,theprescription is contained in Zhang Zhongjing's "Golden Chamber",has been one thousand eight hundred years of history..Huangqi Guizhi Decoction of five ingredients is composed of cassia twig,astragalus,jujube,ginger and peony five Chinese medicinal herbs,can reconcile camp Wei,treatment of blood stagnation of qi stagnation effect in clinic,so farstill used by many people.The party in the modern clinical also has a very wide range of applications,mainly used for the treatment of cervical spondylosis,rheumatism,limb numbness,postpartum disease,diabetic peripheral neuropathy disease.The system of inspection and sorting theAstragalus Decoction of five drugs on ancient and modern literature data,according to the relevant requirements of the national Chinese medicinetechnology,Astragalus Decoction of five drugs prepared Chinese medicine granules,and the extraction technology,granule preparation and its qualitystandard,the initial stability of several aspects of this reviews.Study on the preparation pro cess:This part of the experiment made reference to "use method of Radix Astragali cassia twigs five soup of synopsis of prescriptions of the Golden Chamber",a large amount of literature,to understand the nature of each active ingredient in the prescription,through comparison between the extraction process of traditional and modern extraction technology,consistent in the process of moderntechnology and traditional case,preliminary draft process.Firstly,the medicinal soaking time were investigated,To determine the optimal soaking time,then,the content ofgypsum content,extract content,calycosin glycoside content and paeoniflorin as index,the design of L9(34)orthogonal test,by comparing the four evaluation indexes,so as to determine theextraction time,extraction times and water.,most suitable,drawn up a tentative extraction route,route is added 8 times water first,no medicine,placed for 75 minutes,75 minutes after the heating reflux extraction for 1.5 hours,filtration,filter residue is adding 6 times amount of water,then heating reflux extraction for 1 hours,filtering,merging the filtrate for two times;still abovefour indexes as the indexes,the concentration and drying process was studiedto determine the reasonable conditions,concentration and drying conditions;forming process,investigation of drug and excipient proportion to determine the suitable proportion,i.e.,the drug and excipients proportion is 6:4,detennine the specifications for each bag 10g,take three times a day,a bag each time;the pilot test,to determine a reasonable preparation process,stable,feasible.Study on quality standard:This topic using modern chromatographic technology,the quality standard of Radix Astragali cassia twigs five granule was studied,established a set of perfect quality standards.Firstly,by thin layer chromatography,the three herbs of Radix Paeoniae Alba,Radix Astragali,ginger in the preparation were identified by tlc.The peony of effective components by high-performance liquid chromatography and use of effective components of Radix Astragali of calycosin glycoside and Radix Paeoniae Alba were determined,and the calycosin glycoside for the study methodology,The precision,stability,repeatability,meets the requirements,the recovery in accordance with 95%-105 requirements;results show that the method is specific,property is strong,good reproducibility,the radix astragali cassia twigs five granule comprehensively to establish its quality controlsystem.Study on stability:study on the stability of the time was 6 months,the subject of thespecimens were observed with samples,the index of its appearance,TLC,content respectively at zeroth,1,2,3,6 months were examined,This product indicators stable,in conformity with the quality standards and Chinese"Pharmacopoeia"(2010 Edition)requirements.